Palavras-chave
base de Schiff
atividade antibacteriana
análise espectral
íons metálicos
Como Citar
Resumo
Este estudo tem como objetivo preparar uma nova base de Schiff, a 2-[(E)-[2-(2,4-dinitrofenil)hidrazinilideno]metil]-1H-pirrol (NPHP), derivada da hidrazina 2,4-dinitrofenílica e do 1H-pirrol-2-carbaldeído na proporção de 1:1. Além disso, foram sintetizados dois novos complexos dessa base de Schiff com íons de metais de transição, Ni(II) e Cu(II), com proporção ligante-metal de 2:1. Os complexos foram caracterizados por meio de condutividade molar, FT-IR, UV-Vis, 1HNMR, 13CNMR, XRD e microscopia eletrônica de transmissão. As propriedades físico-químicas e os resultados espectrais indicam que a condutividade apresentou natureza eletrolítica para esses complexos, e o ligante atua como um agente quelante bidentado com geometria octaédrica, conforme comprovado pelas análises FT-IR e UV-Vis. Os átomos de nitrogênio da azometina (CH=N) e do pirrol foram identificados como os sítios de coordenação. Estudos com bactérias patogênicas para o ligante e seus novos complexos, Ni(II) e Cu(II), foram realizados contra Escherichia coli, Staphylococcus aureus e Pseudomonas aeruginosa. Com base na teoria da quelação, os complexos metálicos exibiram maior atividade biológica do que o ligante livre, enquanto o complexo de Ni(II) foi mais eficaz do que o complexo de Cu(II). Notavelmente, a base de Schiff (NPHP) não apresentou atividade contra Escherichia coli.
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