Palavras-chave
atenolol
p-chloranil
pharmaceutical formulations
Como Citar
Resumo
A simple analytical method for quantification of atenolol in pharmaceutical formulations by diffuse reflectance spectroscopy is described. The method is based on the reaction, on the filter paper surface, between the drug and p-chloranil producing a colored compound. The best reaction conditions were obtained with 20 μL of atenolol solution and 20 μL of p-chloranil. All reflectance measurements were carried out at 550 nm and the linear range was from 1.13x10-2 to 7.88x10-2 mol L-1 (r = 0.9992). The limit of detection was 2.80 x 10-3 mol L-1. The proposed method was successfully applied to analysis of different commercial brands of pharmaceutical formulations and the results obtained by the proposed method were in good agreement with those obtained using the British Pharmacopoeia method.
Referências
E. C. Vidotti, W. F. Costa, and C. C. Oliveira, Talanta, 68
(2005) 516.
P. T. Anasta, Crit. Rev. Anal. Chem., 29 (1999) 167.
K. Pastore, Revista Veja, 31 (1998) 40.
L. Pezza, M. Tubino, C. B. Melios, and H. R. Pezza, Anal.
Sci., 16 (2000) 313.
B. B. Hoffman, in: J. G. Hardman, L. E. Limbird, A. G.
Gilman (eds), Goodman & Goodman¥s The Pharmacological
Basis of Therapeutics, tenth ed., MacGraw-Hill, Rio de
Janeiro, v. 10, 1987, p. 1011-1021.
United States Pharmacopeia: USP 26 the national formulary USP 26-NF1, twenty sixth ed. Rockville, MD, 2003.
British Pharmacopoeia Londom: The Stationer Office, v.
, 2001.
Y. K. Agrawal, K. Raman, S. Raiput, and S. K. Menon,
Anal. Lett., 12 (1992) 1503.
A. Gülcü, C. Yücesoy, and S. Serin, Farmaco, 59 (2004) 487.
H. Salem, J. Pharm. Biomed. Anal., 29 (2002) 527.
S. M. Al-Ghannam and F. Belal, J. AOAC Int., 85 (2002)
A. S. Amin, G. H. Ragab, and H. Saleh, J. Pharm.
Biomed. Anal., 30 (2002) 1347.
S. M. Al-Ghannam, J. Pharm. Biomed. Anal., 40 (2006) 151.
M. C. F. Ferraro, P. M. Castellano, and T. S. Kaufman, J.
Pharm. Biomed. Anal., 34 (2004) 305.
D. Bonazzi, R. Gotti, V. Andrisano, and V. Cavrini,
Farmaco, 51 (1996) 733.
I. R. Martinez, M. C. G. A. Coque, and R. M. V. Camanas, J. Chromatogr., A, 765 (1997) 221.
A. P. Argekar, and J. G. Sawant, J. Liq. Chromatogr. Rel.
Technol., 22 (1999) 1571.
A. P. Argekar, and S.G. Powar, Farmaco, 21 (2000) 1137.
D. P. Nikolelis, S. E. Petropoulou, and M. V. Mitrokotsa,
Bioelectrochemistry, 58 (2002) 107.
S. S. M. Hassan, M. M. Abou-Sekkina, M. A. El-Ries,
and A. A. Wassel, J. Pharm. Biomed. Anal., 32 (2003) 175.
M. Shamsipur, and F. Jalali, Anal. Lett., 38 (2005) 401.
P. S. Bonato, A. C. C. Briguenti, Drug Dev. Ind. Pharm.,
(2005) 209.
A. Shafaati and B. J. Clark, Anal. Lett., 14 (1996) 1547.
M. I. Maguregui, R. M. Jimenez, and R. M. Alonso, J.
Chromatogr. Sci., 36 (1998) 516.
R. N. Goyal, V. K. Gupta, M. Oyama, N. Bachheti,
Electrochem. Commun., 8 (2006) 65.
R. N. Goyal, and S. P. Singh, Talanta, 39 (2006) 932.
M. P. Arena, M. D. Porter, J. S. Fritz, Anal. Chim. Acta,
(2003) 197.
S. G. Dmitrienko, O. A. Sviridova, L. N. Pyatkova, V. M.
Senyavin, Anal. Bioanal. Chem. 374 (2002) 361.
F. A. A. Matias, M. M. D. C. Vila, M. Tubino, Sens.
Actuators B, 88 (2003) 60.
A. Ghauch, C. Turnar, C. Fachinger, J. Rima, A. Charef,
J. Suptil, M. Martin-Bouyer, Chemosphere, 40 (2000) 1327.
Y. Moliner-Martinez, P. Campíns-Falcó, Talanta, 65
(2005) 217.
M. Tubino, R. L. Souza, Talanta, 68 (2006) 776.
O. A. Zaporozhets, O. Gawer, V. Sukhan, Talanta, 46
(1998) 1387.
O. A. Zaporozhets, L. Tsyukalo, Talanta, 58 (2002) 861.
F. A. A. Matias, W. A. Oliveira, E. Moschim, Sens.
Actuators B, 41 (1997) 159.
M. A. Gotardo, A. C. Gigante, L. Pezza, H. R. Pezza,
Talanta, 64 (2004) 361.
M. A. Gotardo, L. Pezza, H. R. Pezza, Eclet. Quim., 30
(2005) 17.
M. Tubino, A. V. Rossi, M. E. A. Magalhães, Anal. Lett.,
(1997) 271.
M. A. Korany, A. A. M. Wahbi, Analyst, 104 (1979) 146.
L. I. Bebawy, N. El-Kousy, J. K. Suddik, and M. Shokry,
J. Pharm. Biomed. Anal., 21 (1999) 33.
E. A. Ibrahim, A. S. Issa, M. A. A. Salam, and M. S.
Mahrous, Talanta, 30 (1983) 531.
R. S. Bakry, O. A. Razak, A. F. M. El-Walily, and S. F.
Belal, J. Pharm. Biomed. Anal., 14 (1996) 357.
H. Salem, J. Pharm. Biomed. Anal., 29 (2002) 527.
R. Foster, Organic Charge-Transfer Complexes, 2nd ed.,
Academic Press, London, 1968, p. 470.
D. A. Skoog, F. J. Holler, T. A. Nieman, Principles of
Instrumental Analysis, fifth ed., Harcourt Brace Company,
Philadelphia, 1998, p. 27.
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2018 Eclética Química