Palavras-chave
Sclerocarya birrea
acoplamento molecular
infecções do trato urinário
Como Citar
Resumo
Neste estudo, dois compostos derivados dos componentes bioativos da Sclerocarya birrea (S. birrea), uma planta nativa da Nigéria, foram examinados quanto à sua composição bioquímica, eficácia antibacteriana e estrutura molecular. O pirogalol (94,72 e 46,77%) e a hidroxiquinol, identificada exclusivamente no extrato de hexano, foram os principais componentes bioativos extraídos da planta estudada, S. birrea (52,71%). Um composto químico polifenólico conhecido como pirogalol demonstrou ter ampla atividade antibacteriana. Os extratos de etanol e hexano da casca de S. birrea demonstraram um potencial antibacteriano significativo contra todo o painel de bactérias testadas neste estudo, indicando que os extratos da planta têm uma ampla gama de atividade em comparação com as bactérias de interesse mais frequentemente responsáveis por infecções do trato urinário. Devido à alta concentração fenólica no extrato da casca da planta, os resultados antirradicais também mostraram que S. birrea tinha uma capacidade antioxidante muito significativa. Verificou-se, a partir do acoplamento molecular, que o pirogalol poderia inibir 80% dos receptores estudados.
Referências
Abisoye, L. R. Antimalarial, Antitrypanosomal, Antimicrobial Activities and Volatile Oil Profile of Xylopia aethiopica (Dunal) Rich (Annonaceae). Lett. Appl. NanoBio Sci. 2021, 11, 3897–3908. https://doi.org/10.33263/LIANBS113.38973908
Adeyemi, S.; Larayetan, R.; Onoja, A. D.; Ajayi, A.; Yahaya, A.; Ogunmola, O. O.; Adeyi, A. O.; Chijioke, O. Anti-Hemorrhagic Activity of Ethanol Extract of Moringa Oleifera Leaf on Envenomed Albino Rats. Sci. Afr. 2021, 12, e00742. https://doi.org/10.1016/j.sciaf.2021.e00742
Ait-Mimoune, N.; Hassaine, H.; Boulanoir, M. Bacteriological Profile of Urinary Tract Infections and Antibiotic Susceptibility of Escherichia Coli in Algeria. Iran. J. Microbiol. 2022, 14 (2), 156–160. https://doi.org/10.18502/ijm.v14i2.9180
Akinpelu, D. A.; Abioye, E. O.; Aiyegoro, O. A.; Akinpelu, O. F.; Okoh, A. I. Evaluation of Antibacterial and Antifungal Properties OfAlchornea Laxiflora(Benth.) Pax. & Hoffman. Evid. Based Complement. Alternat. Med. 2015, 2015 (1), 684839. https://doi.org/10.1155/2015/684839
Balouiri, M.; Sadiki, M.; Ibnsouda, S. K. Methods for in Vitro Evaluating Antimicrobial Activity: A Review. J. Pharm. Anal. 2016, 6 (2), 71–79. https://doi.org/10.1016/j.jpha.2015.11.005
Belemnaba, L.; Sawadogo, B.; Ouedraogo, W. R. C.; Nitiéma, M.; Kaboré, B.; Sawadogo, B.; Koala, M.; Ouedraogo, M.; Ouedraogo, S. “Acute Toxicity, Antioxidant and Vasodilatory Properties of Sclerocarya Birrea (A. Rich.) Hochst (Anacardiaceae) Trunk Bark’s Aqueous Decoction”. J. Adv. Med. Pharm. Sci. 2024, 26 (8), 1–19. https://doi.org/10.9734/jamps/2024/v26i8704
Braca, A.; Politi, M.; Sanogo, R.; Sanou, H.; Morelli, I.; Pizza, C.; De Tommasi, N. Chemical composition and antioxidant activity of phenolic compounds from wild and cultivated Sclerocarya birrea (Anacardiaceae) leaves. J. Agric. Food Chem. 2003, 51 (23), 6689–6695. https://doi.org/10.1021/jf030374m
Bravo, L. Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance. Nutr. Rev. 2009, 56 (11), 317–333. https://doi.org/10.1111/j.1753-4887.1998.tb01670.x
Chen, C.-H.; Liu, T.-Z.; Chen, C.-H.; Wong, C. H.; Chen, C.-H.; Lu, F.-J.; Chen, S. C. The Efficacy of Protective Effects of Tannic Acid, Gallic Acid, Ellagic Acid, and Propyl Gallate against Hydrogen Peroxide-Induced Oxidative Stress and DNA Damages in IMR-90 Cells. Mol. Nutr. Food Res. 2007, 51 (8), 962–968. https://doi.org/10.1002/mnfr.200600230
Chew, Y.-L.; Goh, J.-K.; Arasi, C. Investigation on Antibacterial Activity of Pyrogallol in Methicillin Resistant Staphylococcus Aureus. Curr. Trends Biotechnol. Pharm. 2020, 14 (5), 176–180. https://doi.org/10.5530/ctbp.2020.4s.20
Citarasu T. Natural antimicrobial compounds for use in aquaculture. In: Austin B. (ed.) Infectious Disease in Aquaculture. Woodhead Publishing; 2012, p. 419–456.
Collins, C. H.; Lyne, P. M.; Grange, J. M.; Falkinham III, J. O. Collins and Lyne’s Microbiological Methods. Arnolds London UK; 2004.
Cynthia, I. F.; Hery, S.; Akhmad, D. Antibacterial and antioxidant activities of pyrogallol and synthetic pyrogallol dimer. Res. J. Chem. Environ. 2018, 22, 39–48.
Daglia, M. Polyphenols as Antimicrobial Agents. Curr. Opin. Biotechnol. 2012, 23 (2), 174–181. https://doi.org/10.1016/j.copbio.2011.08.007
Daniel, J. A.; Mathiyazhagan, J.; Anbazhagan, M.; Jayaraj, R.; Gothandam, K. M. Phytochemistry and Pharmacology of Sclerocarya birrea (A. Rich.) Hochst.: A Review. Bioact. Pharmacol. Med. Plants. 2022, 139–147. https://doi.org/10.1201/9781003281658-10
Defoirdt, T.; Pande, G. S. J.; Baruah, K.; Bossier, P. The Apparent Quorum-Sensing Inhibitory Activity of Pyrogallol Is a Side Effect of Peroxide Production. Antimicrob. Agents. Chemother. 2013, 57 (6), 2870–2873. https://doi.org/10.1128/AAC.00401-13
Dorothy, V.; Lucy, H.; Sunday, O. O.; Mary, O. U. The Anti-Inflammatory Activities of Twelve Nigerian Medicinal Plants: Inhibition of NfkB, Activation of Nrf2, and Antioxidant Content. Afr. J. Biochem. Res. 2022, 16 (1), 1–10. https://doi.org/10.5897/ajbr2021.1134
Doughari, J. H.; Human, I. S.; Benadé, A. J.; Ndakidemi, P. A. Phytochemicals as chemotherapeutic agents and antioxidants: Possible solution to the control of antibiotic resistant verocytotoxin producing bacteria. J. Med. Plants Res. 2009, 3 (11), 839–848. http://hdl.handle.net/11189/2637s
Dubey, N. K.; Kumar, R.; Tripathi, P. Global promotion of herbal medicine: India’s opportunity. Curr. Sci. 2004, 86 (1), 37–41.
Elzaawely, A. A.; Xuan, T. D.; Tawata, S. Antioxidant and Antibacterial Activities of Rumex Japonicus HOUTT. Aerial Parts. Biol. Pharm. Bull. 2005, 28 (12), 2225–2230. https://doi.org/10.1248/bpb.28.2225
Gadisa, E.; Weldearegay, G.; Desta, K.; Tsegaye, G.; Hailu, S.; Jote, K.; Takele, A. Combined Antibacterial Effect of Essential Oils from Three Most Commonly Used Ethiopian Traditional Medicinal Plants on Multidrug Resistant Bacteria. BMC Complement. Altern. Med. 2019, 19, 24. https://doi.org/10.1186/s12906-019-2429-4
Gauba, A.; Rahman, K. M. Evaluation of Antibiotic Resistance Mechanisms in Gram-Negative Bacteria. Antibiotics. 2023, 12, 1590. https://doi.org/10.3390/antibiotics12111590
Guerrini, A.; Sacchetti, G.; Rossi, D.; Paganetto, G.; Muzzoli, M.; Andreotti, E.; Tognolini, M.; Maldonado, M. E.; Bruni, R. Bioactivities of Piper Aduncum L. and Piper Obliquum Ruiz & Pavon (Piperaceae) essential oils from Eastern Ecuador. Environ. Toxicol. Pharmacol. 2009, 27 (1), 39–48. https://doi.org/10.1016/j.etap.2008.08.002
Hopper, W.; Mahadevan, A. Degradation of catechin by Bradyrhizobium japonicum. Biodegradation. 1997, 8 (3), 159–165. https://doi.org/10.1016/j.etap.2008.08.002
Kagambega, W.; Belem, H.; Meda, R. N.-T.; Koama, B. K.; Drabo, A.-F.; Kabore, J.; Traore, A.; Ouédraogo, G. A.; Benedec, D.; Hanganu, D.; Vlase, L.; Vlase, A.-M.; Voștinaru, O.; Mogoșan, C.; Oniga, I. Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants. Plants. 2022, 11 (10), 1377. https://doi.org/10.3390/plants11101377
Kamatou, G. P. P.; Viljoen, A. M.; Başer, K. H. C. Head-Space Volatiles of Marula (Scelerocarya Birrea, Subspecies Caffra). S. Afr. J. Bot. 2008, 74 (2), 325–326. https://doi.org/10.1016/j.sajb.2007.10.005
Khameneh, B.; Iranshahy, M.; Soheili, V.; Fazly Bazzaz, B. S. Review on Plant Antimicrobials: A Mechanistic Viewpoint. Antimicrob. Resist. Infect. Control. 2019, 8, 118. https://doi.org/10.1186/s13756-019-0559-6
Kim, D.-O.; Jeong, S. W.; Lee, C. Y. Antioxidant Capacity of Phenolic Phytochemicals from Various Cultivars of Plums. Food Chem. 2003, 81 (3), 321–326. https://doi.org/10.1016/s0308-8146 (02)00423-5
Larayetan, R.; Osanekwu, S.; Sokwo, M. Phytochemical Components of Methanolic Fruit Extract of Dennettia tripetala. J. Funct. Mater. Biomol. 2018, 2, 48–52.
Larayetan, R.; Ololade, Z. S.; Ogunmola, O. O.; Ladokun, A. Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon Citrinus. Evid. Based Complement. Alternat. Med. 2019, 2019 (1), 5410923. https://doi.org/10.1155/2019/5410923
Lin, T.-H.; Wu, C.-C.; Tseng, C.-Y.; Fang, J.-H.; Lin, C.-T. Effects of Gallic Acid on Capsular Polysaccharide Biosynthesis in Klebsiella Pneumoniae. J. Microbiol. Immunol. Infect. 2022, 55 (6 Pt 2), 1255–1262. https://doi.org/10.1016/j.jmii.2021.07.002
Louis, H.; Akakuru, O. U.; Linus, M. N.; Innocent, J.; Amos, P. I. Qualitative and Quantitative Phytochemical Analyses of Sclerocarya birrea and Sterculia setigera in Kem and Yola, Adamawa State, Nigeria. Am. J. Biomed. Res. 2018, 6 (1), 1–10. https://doi.org/10.12691/ajbr-6-1-1
Mabasa, L.; Kotze, A.; Shabalala, S.; Kimani, C.; Gabuza, K.; Johnson, R.; Sangweni, N. F.; Maharaj, V.; Muller, C. J. F. Sclerocarya Birrea (Marula) Extract Inhibits Hepatic Steatosis in Db/Db Mice. Int. J. Environ. Res. Public Health. 2022, 19 (7), 3782. https://doi.org/10.3390/ijerph19073782
Maharaj, V.; Ezeofor, C. C.; Naidoo Maharaj, D.; Muller, C. J. F.; Obonye, N. J. Identification of Antidiabetic Compounds from the Hexane Extract of Sclerocarya Birrea Leaves. Molecules. 2022, 27 (22), 8095. https://doi.org/10.3390/molecules27228095
Mahato, S. B.; Sen, S. Advances in Triterpenoid Research, 1990–1994. Phytochemistry. 1997, 44 (7), 1185–1236. https://doi.org/10.1016/s0031-9422 (96)00639-5
Mariod, A. A.; Matthäus, B.; Hussein, I. H. Antioxidant properties of methanolic extracts from different parts of Sclerocarya birrea. Int. J. Food Sci. Technol. 2008, 43 (5), 921–926. https://doi.org/10.1111/j.1365-2621.2007.01543.x
Mashau, M. E.; Kgatla, T. E.; Makhado, M. V.; Mikasi, M. S.; Ramashia, S. E. Nutritional Composition, Polyphenolic Compounds and Biological Activities of Marula Fruit (Sclerocarya Birrea) with Its Potential Food Applications: A Review. Int. J. Food Prop. 2022, 25 (1), 1549–1575. https://doi.org/10.1080/10942912.2022.2064491
Mohammed, A. A.; Samad, A.; Omar, O. A. Escherichia Coli Spp, Staph Albus and Klebseilla Spp Were Affected by Some Antibiotics for Urinary Tract Infections in Bani Waleed City. Brill. Res. Artif. Intell. 2022, 2 (2), 66–70. https://doi.org/10.47709/brilliance.v2i2.1564
Nantitanon, W.; Chowwanapoonpohn, S.; Okonogi, S. Antioxidant and Antimicrobial Activities of Hyptis Suaveolens Essential Oil. Sci. Pharm. 2007, 75 (1), 35–54. https://doi.org/10.3797/scipharm.2007.75.35
Njume, C.; Afolayan, A. J.; Green, E.; Ndip, R. N. Volatile Compounds in the Stem Bark of Sclerocarya Birrea (Anacardiaceae) Possess Antimicrobial Activity against Drug-Resistant Strains of Helicobacter Pylori. Int. J. Antimicrob. Agents. 2011, 38 (4), 319–324. https://doi.org/10.1016/j.ijantimicag.2011.05.002
Nur Saeida, B.; Hasmah, A.; Wan Nor Amilah, W. A. W.; Kerian, K. Potential use of Quercus infectoria gall extracts against urinary tract pathogenic bacteria. Int. J. Res. Pharmacol. Pharmacother. 2014, 3 (3), 184–191.
Obadoni, B. O.; Ochuko, P. O. Phytochemical Studies and Comparative Efficacy of the Crude Extracts of Some Haemostatic Plants in Edo and Delta States of Nigeria. Glob. J. Pure Appl. Sci. 2002, 8 (2), 203–208. https://doi.org/10.4314/gjpas.v8i2.16033
Okwu, D. E.; Okwu, M. E. Chemical Composition of Spondias Mombin Linn Plant Parts. J. Sustain. Agric. Environ. 2004, 6 (2), 140–147.
Ordonez, A.; Gomez, J.; Vattuone, M.; Lsla, M. Antioxidant Activities of Sechium Edule (Jacq.) Swartz Extracts. Food Chem. 2006, 97 (3), 452–458. https://doi.org/10.1016/j.foodchem.2005.05.024
Oyebamiji, A. K.; Soetan, E. A.; Akintelu, S. A.; Ayeleso, A. O.; Mukwevho, E. Alpha-Glucosidase Activity of Phytochemicals from Phyllanthus Amarus Leaves via In-Silico Approaches. Pharmacol. Res. - Mod. Chin. Med. 2022, 2, 100054. https://doi.org/10.1016/j.prmcm.2022.100054
Park, W. H.; Han, Y. W.; Kim, S. H.; Kim, S. Z. A Superoxide Anion Generator, Pyrogallol Induces Apoptosis in As4.1 Cells through the Depletion of Intracellular GSH Content. Mutat. Res. Fundam. Mol. Mech. Mutagen. 2007, 619 (1-2), 81–92. https://doi.org/10.1016/j.mrfmmm.2007.02.004
Reid, G. Urogenital Infections in Women: Can Probiotics Help? Postgrad. Med. J. 2003, 79 (934), 428–432. https://doi.org/10.1136/pmj.79.934.428
Rossiter, S. E.; Fletcher, M. H.; Wuest, W. M. Natural Products as Platforms to Overcome Antibiotic Resistance. Chem. Rev. 2017, 117 (19), 12415–12474. https://doi.org/10.1021/acs.chemrev.7b00283
Russon, D.; Miglionico, R.; Carmosino, M.; Bisaccia, F.; Andrade, P.; Valentão, P.; Milella, L.; Armentano, M. A Comparative Study on Phytochemical Profiles and Biological Activities of Sclerocarya Birrea (A.Rich.) Hochst Leaf and Bark Extracts. Int. J. Mol. Sci. 2018, 19 (1), 186. https://doi.org/10.3390/ijms19010186
Salazar-Orbea, G. L.; García-Villalba, R.; Bernal, M. J.; Hernández, A.; Tomás-Barberán, F. A.; Sánchez-Siles, L. M. Stability of phenolic compounds in apple and strawberry: Effect of different processing techniques in industrial set up. Food Chem. 2023, 401, 134099. https://doi.org/10.1016/j.foodchem.2022.134099
Selvaraj, S.; Rajkumar, P.; Thirunavukkarasu, K.; Gunasekaran, S.; Kumaresan, S. Vibrational (FT-IR and FT-Raman), Electronic (UV–Vis) and Quantum Chemical Investigations on Pyrogallol: A Study on Benzenetriol Dimers. Vib. Spectrosc. 2018, 95, 16–22. https://doi.org/10.1016/j.vibspec.2018.01.003
Shmuely, H.; Ofek, I.; Weiss, E. I.; Rones, Z.; Houri-Haddad, Y. Cranberry Components for the Therapy of Infectious Disease. Curr. Opin. Biotechnol. 2012, 23 (2), 148–152. https://doi.org/10.1016/j.copbio.2011.10.009
Taguri, T.; Tanaka, T.; Kouno, I. Antimicrobial Activity of 10 Different Plant Polyphenols against Bacteria Causing Food-Borne Disease. Biol. Pharm. Bull. 2004, 27 (12), 1965–1969. https://doi.org/10.1248/bpb.27.1965
Tanih, N. F.; Ndip, R. N. Evaluation of the Ethanol and Hexane Extracts of Mature Stem Bark of Sclerocarya Birrea for Antioxidant and Antimicrobial Properties. Evid. Based Complement. Alternat. Med. 2012, 2012, 834156. https://doi.org/10.1155/2012/834156
Tinh, T. H.; Nuidate, T.; Vuddhakul, V.; Rodkhum, C. Antibacterial Activity of Pyrogallol, a Polyphenol Compound against Vibrio Parahaemolyticus Isolated from the Central Region of Thailand. Procedia Chem. 2016, 18, 162–168. https://doi.org/10.1016/j.proche.2016.01.025
Van Buren, J. P.; Robinson, W. B. Formation of Complexes between Protein and Tannic Acid. J. Agric. Food Chem. 1969, 17 (4), 772–777. https://doi.org/10.1021/jf60164a003
Viljoen, A. M.; Guy, P. P.; Kamatou, K.; Başer, K. H. C. Head-space volatiles of marula (Sclerocarya birrea subsp. caffra). S. Afr. J. Bot. 2008, 74 (2), 325–326. https://doi.org/10.1016/j.sajb.2007.10.005
Yadav, M.; Chatterji, S.; Gupta, S. K.; Watal, G. Preliminary phytochemical screening of six medicinal plants used in traditional medicine. Int. J. Pharm. Pharm. Sci. 2014, 6 (5), 539–542.
Zeng, Z.; Zhan, J.; Zhang, K.; Chen, H.; Cheng, S. Global, Regional, and National Burden of Urinary Tract Infections from 1990 to 2019: An Analysis of the Global Burden of Disease Study 2019. World J. Urol. 2022, 40 (3), 755–763. https://doi.org/10.1007/s00345-021-03913-0
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