Antibacterial potential of flavonoids with different hydroxylation patterns
PDF
EPUB

Keywords

flavonoids
antibacterial activity
structure-activity relationships
degree of hydroxylation

How to Cite

Resende, F. A., Nogueira, L. G., Bauab, T. M., Vilegas, W., & Varanda, E. A. (2016). Antibacterial potential of flavonoids with different hydroxylation patterns. Eclética Química, 40(1), 173–179. https://doi.org/10.26850/1678-4618eqj.v40.1.2015.p173-179

Abstract

The antibacterial activity of ten flavonoids, with variations in the hydroxylation pattern, was assayed in this study with the aim of investigating the influence of the hydroxyl groups of flavonoids on the evaluated activity. The evaluated degree of hydroxylation of the flavonoid molecules appears to have a crucial role in antibacterial effects. Kaempferol, the most active compound against Staphylococcus aureus, has a hydroxyl group in the B ring, a double bond between carbons 2 and 3 in conjunction with a 4-carbonyl group and hydroxyl groups at positions 3, 5 and 7, showing that the hydrophilic / lipophilic balance appears to be an important variable for antibacterial activity. With respect to the strain of Escherichia coli, the compounds evaluated did not inhibit completely bacterial growth; however they reduced the percentage of Gram-negative cells, under the conditions used in this work. These studies contribute to clarify the mechanisms by which these compounds act in the evaluated activity, since flavonoids can act through different mechanisms other than conventional antibiotics and could, therefore, be of use in the treatment of resistant bacteria.

https://doi.org/10.26850/1678-4618eqj.v40.1.2015.p173-179
PDF
EPUB
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2017 Eclética Química Journal

Metrics

PDF views
337
Jan 2017Jul 2017Jan 2018Jul 2018Jan 2019Jul 2019Jan 2020Jul 2020Jan 2021Jul 2021Jan 2022Jul 2022Jan 2023Jul 2023Jan 2024Jul 2024Jan 2025Jul 2025Jan 202624
|
Other format views
6