Potentiometric determination of captopril in pharmaceutical formulations
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Abstract
form and in pharmaceutical preparations is proposed. Captopril present in tablets containing known
quantity of drug was potentiometrically titrated in aqueous solution with NaOH using a glass pH elec-
trode, coupled to an autotitrator. No interferences were observed in the presence of common compo-
nents of the tablets as lactose, microcrystalline cellulose, croscarmellose sodium, starch and magnesium
stearate. The analytical results obtained by applying the proposed method compared very favorably with
those obtained by the United States Pharmacopoeia Standard procedure. Recovery of captopril from
various tablet dosage formulations range from 98.0 to 102.0%.
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