Argentimetric assay of ranitidine in bulk drug and in dosage forms
PDF

Keywords

ranitidine
assay
silver nitrate
pharmaceuticals
spectrophotometry
titrimetry

How to Cite

Basavaiah, K., & Somashekar, B. C. (2007). Argentimetric assay of ranitidine in bulk drug and in dosage forms. Eclética Química, 32(1), 19–26. https://doi.org/10.26850/1678-4618eqj.v32.1.2007.p19-26

Abstract

Two simple, rapid and cost-effective methods based on titrimetric and spectrophotometric
techniques are described for the assay of RNH in bulk drug and in dosage forms using silver nitrate, mer-
cury(II)thiocyanate and iron(III)nitrate as reagents. In titrimetry, an aqueous solution of RNH is treated
with measured excess of silver nitrate in HNO 3 medium, followed by determination of unreacted silver
nitrate by Volhard method using iron(III) alum indicator. Spectrophotometric method involve the addi-
tion a known excess of mercury(II)thiocyanate and iron(III)nitrate to RNH, followed by the measurement
of the absorbance of iron(III)thiocyante complex at 470 nm. Titrimetric method is applicable over 4-30
mg range and the reaction stoichiometry is found to be 1:1 (RNH: AgNO 3 ). In the spectrophotometric
method, the absorbance is found to increase linearly with concentration of RNH which is corroborated
by the correlation coefficient of 0.9959. The system obey Beer’s law for 5-70 μg mL -1 . The calculated
apparent molar absorptivity and sandell sensitivity values are found to be 3.27 × 10 3 L mol -1 cm -1 , 0.107
μg cm -2 respectively.

https://doi.org/10.26850/1678-4618eqj.v32.1.2007.p19-26
PDF

References

J.F.E. Reynolds, A. Martizdale, In: The Extra

Pharmacopoeia, The Pharmaceutical Press, London, 31st

ed.,1996, pp. 1231.

The Indian Pharmacopeia The Controller of Publications,

Ministry of Health and Family Welfare, Govt. of India, New

Delhi, 1996, pp. 659.

T. Ozden, A. Ungovmus, A. Tosun, S. Erasan,

Spectroscop. Lett., 30 (1997) 835.

Q. Wang, S. Delerus, J. Near Infrared Spectroscop., 6

(1998) 223.

E. Dreassi, G. Caramelli, P. Corti, P.L. Perruccio, S.

Lonardi, Analyst, 121 (1996) 219.

S. Fenwick, W.N. Jenner, P. Linacre, R.M. Rooney, S.A.

Ring, Anal. Proc., 31 (1994) 103.

C. Lopez – Erroz, P. Vinas, N. Campillo, M. Hernandez –

Cardoba, Analyst, 121 (1996) 1043.

N.W. Barnett, B.J. Hindson, S.W. Lewis, Anal. Chim.

Acta, 384 (1999) 151.

P. Richter, M.I. Toral, F. Munoz-Varzas, Analyst, 119

(1994) 1371.

M. D. Zamerreno, J. Hernandez-Mendez, A. S. Perez,

Anal. Chim. Acta, 176 (1985) 279.

P.S. Sankar, S.J. Reddy, Indian J. Pharm Sci. 51 (1989) 263.

M.A. Kelly, K.D. Altria, C. Grace, B.J. Clark, J.

Chromatogr., 798 (1996) 297.

H.Y. Aboul-Enien, M. Rafiqui-Islam, Toxicol. Environ.

Chem., 29 (1990) 47.

G. Bettermann, S. Cabrera, S. Heizenroeder, D. Lubda,

Labor Praxis, 22 (1998) 30.

G.L. Iloyer, J. Le Doux, P.E. Nolan Jr., J. Liq.

Chromatogr., 18 (1995) 1239.

C.A. Lau-Cam, M. Rahman, R.W. Ross, J. Liq.

Chromatogr., 17 (1994) 1089.

V. Das Gupta, Drug Dev. Ind. Pharm., 14 (1988) 1647.

N. Beaulieu, P.M. Lacroix, R.W. Sears, E.G. Lovering, J.

Pharm. Sci., 77 (1988) 889.

E.M. Hassan, F. Belal, J. Pharm. Biomed. Anal., 27

(2002) 31.

Z. Atkosar, Acta Pharm. Turc., 31(1989) 139.

K. Basavaiah, P. Nage Gowda, Indian Pharmacist, 3 (24)

(2004) 60.

C.S.P. Sastry, S.G. Rao, J.S.V.M.L. Rao, P.Y. Naidu,

Anal. Lett. 30 (1997) 2377.

A.S. Amin, I.S. Ahmed, H.A. Dessouki, E.A. Gouda,

Spectrochimica Acta Part A, 59 (2003) 695.

E. V. Rao, J. J. Rao, S.S.N. Murthy, G. R. Rao, Indian J.

Pharm, Sci., 49 (1987) 143.

S. Al. Ghannam, F. Belal, J. AOAC Intl., 85 (2002) 1003.

J. Emmanuel, S.D. Haldankar, Indian Drugs, 26 (1989)

S.S.M. Hassan, M.H.M. Mahamoud, A.H.M. Othman,

Anal. Chim. Acta, 332 (1996).

K.N. Raut, S.D. Sabnis, Indian J. Pharm Sci., 49 (1987) 65.

Y. Ozsoy, B. Guvner, Acta Pharm. Turc., 29 (1987) 13.

K. Basavaiah, P. N. Gowda, Indian Pharmacist, 2(14)

(2003) 75.

K. Basavaiah, P. N. Gowda, Indian J. Chem. Technol., 11

(2004) 11.

A.I. Vogel, “A Text Book of Quantitative Inorganic

Analysis”, 5th edn., ELBS

London, 1991, p. 349. 353.- 3rd edn., ELBS, London, 1969,

p. 78.

C.H. Wilkinson, R. Cole, J. Hosp. Pharm., 26 (1969) 45.

H. Jin, T. Yao, F. Hauxue, 10 (1982) 189.

J.R. Caldwell, H.V. Moyer, Ind. Eng. Chem. Anal., Ed.,

(1935) 38.

D.M. Zall, D. Fisher, M.Q. Garmer, Anal. Chem., 28

(1956) 1665.

T.M. Florence, Y.J. Farrar, Anal. Chim. Acta, 54 (1971)

R. Krishnamurthy, K.A. Bhagawat, Indian J. Exptl. Biol.,

(1990) 198.

O.W. Lau, C.S. Mok, J. Sci. Food. Agri., 31 (1980) 1275.

M.A. Herrero, J. Atiemza, R. P. Maquieira, Analyst, 117

(1992) 1019.

International Conference on Hormonisation of Technical

Requirements for Registration of Pharmaceuticals for Human

Use, ICH Harmonised Tripartite Guideline, Validation of

Analytical Procedures: Text and Methodology Q2(R 1),

Complementary Guideline on Methodology dated 06

November 1996, incorporated in November 2005, London.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2018 Eclética Química Journal

Metrics

PDF views
36
Jul 2007Jan 2008Jul 2008Jan 2009Jul 2009Jan 2010Jul 2010Jan 2011Jul 2011Jan 2012Jul 2012Jan 2013Jul 2013Jan 2014Jul 2014Jan 2015Jul 2015Jan 2016Jul 2016Jan 2017Jul 2017Jan 2018Jul 2018Jan 2019Jul 2019Jan 2020Jul 2020Jan 2021Jul 2021Jan 2022Jul 2022Jan 2023Jul 2023Jan 2024Jul 2024Jan 2025Jul 2025Jan 20269
|