Simple and sensitive spectrophotometric methods for the determination of acebutolol hydrochloride in bulk sample and pharmaceutical preparations

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Published: Jun 23, 2008
DOI: https://doi.org/10.26850/1678-4618eqj.v33.2.2008.p37-40
Keywords:
acebutolol hydrochloride, spectrophotometry, pharmaceutical preparations

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Hadagali D. Manjunatha
Karnatak University, Department of Chemistry, Dharwad, India.
Sarfaraj Mohd Takhi Shaikh
Karnatak University, Department of Chemistry, Dharwad, India.
Kasalanti Harikrishna
Karnatak University, Department of Chemistry, Dharwad, India.
Ramanaboyina Sudhirkumar
Karnatak University, Department of Chemistry, Dharwad, India.
Pradeep Basavaraj Kandagal
Karnatak University, Department of Chemistry, Dharwad, India.
Jaldappa Seetharamappa
Karnatak University, Department of Chemistry, Dharwad, India.

Abstract

A direct, extraction-free spectrophotometric method has been developed for the determination of acebutolol hydrochloride (ABH) in pharmaceutical preparations. The method is based on ionpair complex formation between the drug and two acidic dyes (sulphonaphthalein) namely bromocresol green (BCG) and bromothymol blue (BTB). Conformity to Beer’s law enabled the assay of the drug in the range of 0.5-13.8 μg mL-1 with BCG and 1.8-15.9 μg mL-1 with BTB. Compared with a reference method, the results obtained were of equal accuracy and precision. In addition, these methods were also found to be specific for the analysis of acebutolol hydrochloride in the presence of excipients, which are co-formulated in the drug.

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How to Cite
Manjunatha, H. D., Shaikh, S. M. T., Harikrishna, K., Sudhirkumar, R., Kandagal, P. B., & Seetharamappa, J. (2008). Simple and sensitive spectrophotometric methods for the determination of acebutolol hydrochloride in bulk sample and pharmaceutical preparations. Eclética Química, 33(2), 37–40. https://doi.org/10.26850/1678-4618eqj.v33.2.2008.p37-40
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Vol. 33 No. 2 (2008): Eclética Química
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Original articles
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