Simple and sensitive spectrophotometric methods for the determination of acebutolol hydrochloride in bulk sample and pharmaceutical preparations
Vol. 33 No. 2 (2008), Original articles
Vol. 33 No. 2 (2008)

Simple and sensitive spectrophotometric methods for the determination of acebutolol hydrochloride in bulk sample and pharmaceutical preparations

Original articles
https://doi.org/10.26850/1678-4618eqj.v33.2.2008.p37-40
Published 2008-06-23
Hadagali D. Manjunatha
Karnatak University, Department of Chemistry, Dharwad, India.
Sarfaraj Mohd Takhi Shaikh
Karnatak University, Department of Chemistry, Dharwad, India.
Kasalanti Harikrishna
Karnatak University, Department of Chemistry, Dharwad, India.
Ramanaboyina Sudhirkumar
Karnatak University, Department of Chemistry, Dharwad, India.
Pradeep Basavaraj Kandagal
Karnatak University, Department of Chemistry, Dharwad, India.
Jaldappa Seetharamappa
Karnatak University, Department of Chemistry, Dharwad, India.
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Keywords

acebutolol hydrochloride
spectrophotometry
pharmaceutical preparations

How to Cite

Manjunatha, H. D., Shaikh, S. M. T., Harikrishna, K., Sudhirkumar, R., Kandagal, P. B., & Seetharamappa, J. (2008). Simple and sensitive spectrophotometric methods for the determination of acebutolol hydrochloride in bulk sample and pharmaceutical preparations. Eclética Química, 33(2), 37–40. https://doi.org/10.26850/1678-4618eqj.v33.2.2008.p37-40
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Abstract

A direct, extraction-free spectrophotometric method has been developed for the determination of acebutolol hydrochloride (ABH) in pharmaceutical preparations. The method is based on ionpair complex formation between the drug and two acidic dyes (sulphonaphthalein) namely bromocresol green (BCG) and bromothymol blue (BTB). Conformity to Beer’s law enabled the assay of the drug in the range of 0.5-13.8 μg mL-1 with BCG and 1.8-15.9 μg mL-1 with BTB. Compared with a reference method, the results obtained were of equal accuracy and precision. In addition, these methods were also found to be specific for the analysis of acebutolol hydrochloride in the presence of excipients, which are co-formulated in the drug.
https://doi.org/10.26850/1678-4618eqj.v33.2.2008.p37-40
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