Di- and tri-hydroxylated kaurane derivatives from microbial transformation of ent-Kaur-16-en-19-ol by Cephalosporium aphidicola and their allelopathic activity on Lactuca sativa (Lettuce)

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Published: Mar 2, 2009
DOI: https://doi.org/10.26850/1678-4618eqj.v34.1.2009.p57-62
Keywords:
biotransformations, Cephalosporium aphidicola, ent-kaur-16-en-19-ol, ent-kauran-16β, 19-diol, ent-kauran-16β,17, 19-triol

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Diana Rocha
Universidade Federal de Minas Gerais, Instituto de Ciências Exatas, Belo Horizonte, Brasil.
Jacqueline Aparecida Takahashi
Universidade Federal de Minas Gerais, Instituto de Ciências Exatas, Belo Horizonte, Brasil.
Maria Amelia Diamantino Boaventura
Universidade Federal de Minas Gerais, Instituto de Ciências Exatas, Belo Horizonte, Brasil.
https://orcid.org/0000-0002-7741-1575

Abstract

The use of microorganisms to induce chemical modifications in organic molecules is a very useful tool in organic synthesis, to obtain biologically active substances. The fungus Cephalosporium aphidicola is known by its ability to hydroxylate several skeleton positions of many classes of organic compounds. In this work, the microbial transformation of ent-kaur-16-en-19-ol (1) by C. aphidicola, afforded two hydroxylated compounds, ent-kauran-16b,19-diol (2) and ent-kauran-16b,17,19-triol (3). Their structures were established by 1D and 2D-NMR studies. Both compounds were tested for their action on the growth of radical and shoot of Lactuca sativa.

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How to Cite
Rocha, D., Takahashi, J. A., & Boaventura, M. A. D. (2009). Di- and tri-hydroxylated kaurane derivatives from microbial transformation of ent-Kaur-16-en-19-ol by Cephalosporium aphidicola and their allelopathic activity on Lactuca sativa (Lettuce). Eclética Química, 34(1), 57–62. https://doi.org/10.26850/1678-4618eqj.v34.1.2009.p57-62
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Vol. 34 No. 1 (2009): Eclética Química
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Original articles
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