New reagents for the spectrophotometric determination of ranitidine hydrochloride

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Published: Sep 30, 2010
DOI: https://doi.org/10.26850/1678-4618eqj.v35.3.2010.p109-115
Keywords:
spectrophotometry, ranitidine hydrochloride, ceric ammonium sulphate, malachite green, crystal violet

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Badiadka Narayana
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Karnataka, India.
https://orcid.org/0000-0001-8945-4516
Kunnummel Veena
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Karnataka, India.
Krishnamurthy Ashwani
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Karnataka, India.
Divya Narayana Shetty
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Karnataka, India.

Abstract

A new spectrophotometric method is proposed for the assay of ranitidine hydrochloride (RNH) in bulk drug and in its dosage forms using ceric ammonium sulphate (CAS) and two dyes, malachite (MAG) green and crystal violet (CV) as reagents. The method involves the addition of a known excess of ceric ammonium sulphate to ranitidine hydrochloride in acid medium, followed by the determination of unreacted CAS by reacting with a fixed amount of malachite green or crystal violet and measuring the absorbance at 615 or 582 nm respectively against the reagent blank. The Beer’s law is obeyed in the concentration range of 0.4-8.0 μg/ml of ranitidine hydrochloride (RNH) for RNH-MAG system and 0.2-1.6μg/ml of ranitidine hydrochloride for RNH-CV system. The molar Absorptivity, Sandell’s sensitivity for each system were calculated. The method has been successfully applied to the determination of ranitidine hydrochloride in pure and dosage forms.

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Narayana, B., Veena, K., Ashwani, K., & Shetty, D. N. (2010). New reagents for the spectrophotometric determination of ranitidine hydrochloride. Eclética Química, 35(3), 109–115. https://doi.org/10.26850/1678-4618eqj.v35.3.2010.p109-115
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Vol. 35 No. 3 (2010): Eclética Química
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Original articles
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