Keywords
tropaeoline OO dye
drugs
spectrophotometry
How to Cite
Abstract
A spectrophotometric method has been proposed to determine the proton pump inhibitors omeprazole and pantoprazole sodium in both pure and pharmacological forms, such as injections, capsules, and tablets. The method relied on the reaction of the above drugs with tropaeoline OO dye, forming ion association complexes, which are measured at 410 nm after extraction by chloroform. The method followed Beer's law over the concentration range of 0.5-14 and 0.5–13 μg/mL and with molar absorptivity values of 1.72x10–5 and 1.83x10–5 L mol–1 cm–1 for omeprazole and pantoprazole sodium, respectively. The method had good accuracy and precision, with the recovery % ranging between 98.84 and 101.02% and the relative standard deviation less than 0.66%. The method was successfully applied to pharmaceutical preparations of the studied drug compounds from different origins, and its results were in good agreement with the original content of the pharmaceutical preparations and free from interferences by excipients.
References
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