Radiopharmaceuticals for diagnosis in nuclear medicine: a short review
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Abstract
Radiopharmaceuticals are radioactive compounds which have a bound radionuclide in their structure, whose purpose is directing the radionuclide to a location to be treated or to obtain images. Nuclear medicine is the medical specialty that employs radiopharmaceuticals, which has presented itself as a tremendously useful ally for medicine assisting in various diagnoses and treatments, especially for cancer. The general objective of this work is to identify the main radionuclides and metal complexes currently used as radiopharmaceuticals. The main metal complexes used as radiopharmaceuticals are compounds of technetium (99mTc) like sodium pertechnetate and methylenediphosphonate MDP-99mTc and other compounds of indium (111In), thallium (201Tl), gallium (67Ga, 68Ga), iodine (123I and 131I), chromium (51Cr), sulphur (35S), phosphorus (32P), fluorine (as fluorodeoxyglucose, 18F-FDG and sodium fluorine, Na18F), which are widely used in the nuclear medicine for diagnosis by imaging. They have been of great importance for the early diagnosis of numerous diseases, mainly cancer. Currently, technetium compounds are the majority of radiopharmaceuticals used in all countries. In Brazil, Institute of Energy and Nuclear Research (IPEN) is one of the most important distributors of radiopharmaceuticals, producing, importing and distributing them to clinics and hospitals over the country.
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References
World Health Organization (WHO). Diagnostic imaging. Nuclear Medicine. https://www.who.int/diagnostic_imaging/imaging_modalities/dim_nuclearmed/en/.
Cherry, S. R., Sorenson, J. A., Phelps, M. E. Physics in Nuclear Medicine. Elsevier Inc. ISBN 978-1-4160-5198-5 2012. https://www.sciencedirect.com/topics/neuroscience/radiopharmaceuticals.
International Atomic Energy Agency (IAEA). Operational guidance on hospital radiopharmacy : a safe and effective approach. Vienna: International Atomic Energy Agency, 2008. ISBN 978-92-0-106708-1. https://www-pub.iaea.org/MTCD/publications/PDF/Pub1342/Pub1342_web.pdf.
Ziessman, H. A., O’Malley, J. P., Thrall, J. H. (eds.). Radiopharmaceuticals, In: Nuclear Medicine, 4th ed., W. B. Saunders: Philadelphia, USA, 2014, ch. 1. ISBN 9780323082990. https://doi.org/10.1016/B978-0-323-08299-0.00001-8.
Malley, M. C., Radioactivity: a history of a mysterious science, Oxford University Press, New York, 2011, ISBN 978-0-19-976641-31.
L’Annunziata, M. F., Radioactivity: introduction and history, from the quantum to quarks, Elsevier, 2nd ed., 2016. eBook ISBN: 9780444634962.
Robilotta, C. C., A tomografia por emissão de pósitrons: uma nova modalidade na medicina nuclear brasileira, Rev. Panam. Salud Pública 20 (2/3) (2006) 134-42. https://doi.org/10.1590/S1020-49892006000800010.
Santos-Oliveira, R., Carneiro-Leão, A. M. A., A história da radiofarmácia e as implicações da Emenda Constitucional nº 49. Rev. Bras. Cienc. Farm. 44 (3) 2008. http://qnesc.sbq.org.br/online/cadernos/06/a08.pdf.
Comissão Nacional de Energia Nuclear (CNEN), RMB e a Produção de Radiofármacos. http://www.cnen.gov.br/radiofarmacos.
Wells, R. G., Instrumentation in molecular imaging. J. Nucl. Cardiol. 23 (6) 2016, 1343-1347. https://doi.org/10.1007/s12350-016-0498-z.
World Nuclear Association (WNA). Radionuclides in medicine. (Updated November 2018). http://www.world-nuclear.org/information-library/non-power-nuclear-applications/radionuclides-research/radionuclides-in-medicine.aspx.
K, Seyed. Molecular Nuclear Imaging: The Radiopharmaceuticals (Review) .Cancer Biotherapy and Radiopharmaceuticals, 20 (2) 2005. https://doi.org/10.1089/cbr.2005.20.163.
Comissão Nacional de Energia Nuclear (CNEN), Ministério da Ciência, Tecnologia, Inovação e Comunicações, Relatório de Gestão do exercício de 2017. http://www.cnen.gov.br/images/cnen/documentos/acesso_a_informacao/Rel-gestao-2017.pdf.
European Organization for Nuclear Research (CERN), A table of frequently used radioisotopes – CERN Document Server. C. Grupen, Introduction to Radiation Protection, Graduate Texts in Physics, 2010. https://doi.org/10.1007/978-3-642-02586-0.
Wikimedia Commons, the free media repository, ‘File: Female shadow template.svg’. https://commons.wikimedia.org/w/index.php?title=File:Female_shadow_template.svg&oldid=302058264.
Amazônia Azul Tecnologias de Defesa S.A. (Amazul), Reator Multipropósito Brasileiro. https://www.marinha.mil.br/amazul/acesso-a-informacao/acoes-e-programas/programas/reator-multiproposito-brasileiro.
Instituto de Pesquisas Energéticas e Nucleares (IPEN). Brazilian Multipurpose Reactor – Progress Report. 6 p. 2016. https://www.ipen.br/portal_por/conteudo/documentos/PR_2014_2016_13_Brazilian_Multipurpose_Reactor.pdf.
Pozzo, L., Coura Filho, G., Osso Júnior, J. A., Squair, P. L., SUS in nuclear medicine in Brazil: analysis and comparison of data provided by Datasus and CNEN, Radiol. Bras., 47 (3) (2014) 141-148. https://doi.org/10.1590/0100-3984.2013.1906.
Nuclear Energy Agency (NEA), Steering Committee For Nuclear Energy, High-Level Group on the Security of Supply of Medical Radioisotopes, The supply of medical radioisotopes – 2018 medical isotope demand and capacity projection for the 2018-2023 period. http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=NEA/SEN/HLGMR(2018)3&docLanguage=En.
International Atomic Energy Agency (IAEA). Activity measurement principles. https://humanhealth.iaea.org/HHW/MedicalPhysics/NuclearMedicine/ActivityMeasurements/ActMeasPrinciples/index.html.
Comissão Nacional de Energia Nuclear (CNEN), Instalações Autorizadas. Produção de Radioisótopos (Cíclotron) – Posição em 02/06/2019. http://appasp.cnen.gov.br/seguranca/cons-ent-prof/lst-entidades-aut-cert.asp?p_ent=22&d=Produção de Radioisótopos (Ciclotron).
Pixabay. 'File: brazil-23553_960_720.png'. Pixabay, 2 Apr. 2012. Available from: https://pixabay.com/pt/vectors/brasil-mapa-américa-do-sul-estados-23553/.