Keywords
Corantes
Medicamentos
Títulação ácido-base
How to Cite
Abstract
No presente trabalho desenvolveu-se metodologia simplificada para análise de hexametilenotetramina em medicamentos que apresentam corantes em sua formulação (azul de metileno, Ponceau Red, Bordeaux Red, acriflavina) seguida por titulação ácido-base usando indicador. O método foi aplicado com sucesso a amostras comerciais e os resultados obtidos foram comparados com aqueles encontrados por titulação potenciométrica, apresentando muito boa concordância. Recobrimentos situaram-se na faixa de 101,3 – 104,2%, com desvios padrão de 0,1 – 2,1.
References
BIRYUK, I. A.; PETRENKO, V. V. Spectrophotometric determination of hexamethylenetetramine by reaction with ninhydrin. Zaparozh' e Medical Institute. Z. Anal. Khim., v.48, n.1, p.187-9, 1993. [ Links ]
DOHNAL, J.; VYTRAS, K.; JELINEK, I.; VOLKOVA, Z.; WOHLGEMUTHOVA, H. Methenamine content determination the enteric-coated tablets of methenamine hippurate by titrating with sodium tetraphenylborate by ion-selective electrode. Cesk-Farm., v.38, n.2, p.56-9, 1989. In: Anal. Abstr. Abstr. 1980-2000. Abstract n. 5202E00020. ON-LINE. [ Links ]
DOW, M. L. Semiautomated colorimetric determination of methenamine and methenamine mandelate in tablets. J. A.O.A.C., vol.56, n.3, p.647-52, 1973. [ Links ]
GAGLIA, C. A. Jr.; GOSSER, L.A.; CHAFETZ, L. Methenamine mandelate assay procedures based on a 2:1 silver nitrate-methenamine complex. Anal. Chem., v.44, p.1690-2, 1972. [ Links ]
GORDON, P.F.; GREGORY, P. Organic chemistry in colour. Berlin and New York: Springer-Verlag. 1983. p. 262-72. [ Links ]
HARDMAN, J. G.; GILMAN A. G.; LIMBRID, L. E. In: (Eds.) Goodman & Gilman's the pharmacological basis of therapeutics. 9th ed. WONSIEWICZ, J. M. And MACCURDY, P. New York: Mc Graw-Hill. 1996. p.1068-9. [ Links ]
ILER, R. K. The chemistry of silica. New York: Wiley. 1979. 687p. [ Links ]
KARTSOVA, L. A.; MAKAROVA, Y. L.; STOLIAROV, B. V. Selective gas-cromatographic determination of formaldehyde in air . J. Anal. Chem., v. 52, n. 4, p 337-40, 1997. [ Links ]
KOUPPARIS, M. A.; EFSTATHIOU, C. E.; HADJIIOANNOU, T. P. Kinetic determination of formaldehyde and hexamethylenetetramine with a cyanide-selective electrode. Anal. Chim. Acta, v.107, p.91-100, 1979. [ Links ]
LEVIN, J. O.; FANGMARK, I. High-performance liquid cromatographic determination of hexamethylenetetramine in air. Analyst, v.113, p.511-3, 1988. [ Links ]
LIM, J.K.; CHEN, C. C. C. Spectrophotometric determination of methenamine and its salts by 2-hidrazinobenzothiazole. J. Pharm. Sci., v.62, p.1503-4, 1973. [ Links ]
MADSEN, G.L.; CRUMRINE, D. S.; JASELSKIS, B. Proton nuclear magnetic ressonance determination of hexamethylenetetramine in presence of formaldehyde and urine. Analyst, v.121, p.567-70, 1996. [ Links ]
MADSEN, G.L.; JASELKIS, B. Spectrophotometric determination of hexamethylenetetramine, Analyst, v.117, p.1785-8, 1992. [ Links ]
MELO, J. M. S. Dicionário de especialidades farmacêuticas. 27.ed. Rio de Janeiro: Edit Publicações Centíficas, 1998. p.105. [ Links ]
METHENAMINE. Disponível em http://www.mayohealth.org/usp/html/202075.htm. Acesso em 02/10/2000. [ Links ]
MIRZA, T.; GEORGE, R. C.; BODENMILLER, J. R.; BELANICH, S. A. Capillary gas cromatographic assay of residual methenamine hippurate in equipment cleaning validation swabs. J. Pharm. Biom. Anal, v.16, n.6, p939-50, 1998. [ Links ]
ONUR, F.; ACAR, N. Simultaneous determination of methylene blue, hexamethylenetetramine and resorcinol in pharmaceutics formulations by first derivative UV spectrophotometry. Int. J. Pharm., v.78, n.1, p.89-91, 1992. [ Links ]
PESSOA, C.A.; GUSHIKEM,Y.; KUBOTA, L.T.; GORTON, L.; Preliminary electrochemical study of phenothiazines and phenoxazines immobilized on zirconium phosphate. J. Electroanal. Chem., v.431, n.1, p.23-7, 1997. [ Links ]
ROCHA R.F.; ROSATTO, S.S.; BRUNS, R.E.; KUBOTA, L.T. Factorial design optimization of redox properties of methylene blue adsorbed on a modified silica gel surface. J. Electroanal. Chem., v.433, n.1-2, p.73-6, 1997. [ Links ]
SLUSANSCHI, H. Gravimetric determination of formaldehyde and hexamethylenetetramine with dimedom. Z. Lebensm-Untersuch u-Forsch, v.112, p.350-1, 1960. [ Links ]
STROM, J. G.; JUM, H. W. GLC determination of methenamine in tablets. J. Pharm. Sci., v.66, p 589-90, 1977. [ Links ]
TAHA, A. M.; El-RABBAT, N. A.; FATTAH, A. M. Spectrophotometric assay of hexamethylenetetramine. Analyst, v.105, p.568-74, 1980. [ Links ]
TININIS, A. G.; LEANDRO, A.; PEZZA, H. R.; MELIOS, C. B.; PEZZA, L. Rapid spot test analysis for the detection of urotropine in pharmaceutical preparations. Anal. Lett., v.33, n.14, p.2901-12, 2000. [ Links ]
TURCZAN, J. W.; GOLDWITZ, B. A. Nuclear magnetic-resonance analysis of pharmaceuticals .9. methenamine and methenamine mandelate in tablets. J. A.O.A.C., v.56, n.3, p.669-73, 1973. [ Links ]
UNITED STATES PHARMACOPEIAL CONVENTION. The United States pharmacopeia: The national formulary: methenamine. 23.ed. Revision. Rockville: 1995. p.976-9. [ Links ]
VOGEL, A. Análise inorgânica quantitativa. 4.ed. Rio de Janeiro: Guanabara. 1986. [ Links ]
WINDHOLZ, M.(Ed.). The merck index. Raway: Merck, 1976. p.778. [ Links ]
ZHANTALAI, B. P.; RUCH'EVA, N. I. Polarografic determination of hexamethylenetetramine. Zh. Prikl. Khim., v.39, n.10, p.2339-43, 1966. In: Chem. Abstr., v.66, 16416p, 1967. [ Links ]
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