Spectrophotometric flow injection procedure to indirect determination of paracetamol in pharmaceutical formulations using o-tolidine as reagent

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Published: Jun 23, 2008
DOI: https://doi.org/10.26850/1678-4618eqj.v33.2.2008.p47-53
Keywords:
paracetamol, pharmaceutical analysis, flow injection analysis, spectrophotometry

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Orlando Fatibello-Filho
Universidade Federal de São Carlos, Centro de Ciências Exatas e de Tecnologia, São Carlos, Brasil.
https://orcid.org/0000-0002-6923-2227
Heberth Juliano Vieira
Universidade Federal de São Carlos, Centro de Ciências Exatas e de Tecnologia, São Carlos, Brasil.
https://orcid.org/0000-0002-4917-8825

Abstract

A spectrophotometric flow injection method for the determination of paracetamol in pharmaceutical formulations is proposed. The procedure was based on the oxidation of paracetamol by sodium hypochloride and the determination of the excess of this oxidant using o-tolidine dichloride as chromogenic reagent at 430 nm. The analytical curve was linear in the paracetamol concentration range from 8.50 x 10-6 to 2.51 x 10-4 mol L-1 with a detection limit of 5.0 x 10-6 mol L-1. The relative standard deviation was smaller than 1.2% for 1.20 x 10-4 mol L-1 paracetamol solution (n = 10). The results obtained for paracetamol in pharmaceutical formulations using the proposed flow injection method and those obtained using a USP Pharmacopoeia method are in agreement at the 95% confidence level.

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How to Cite
Fatibello-Filho, O., & Vieira, H. J. (2008). Spectrophotometric flow injection procedure to indirect determination of paracetamol in pharmaceutical formulations using o-tolidine as reagent. Eclética Química, 33(2), 47–53. https://doi.org/10.26850/1678-4618eqj.v33.2.2008.p47-53
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Vol. 33 No. 2 (2008): Eclética Química
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Original articles
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