Inhibitors of human collagenase, MMP1
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Keywords

collagenase
MMP-1
human metalloproteinases
inhibitors
docking

How to Cite

Leite, S. R. de A. (2009). Inhibitors of human collagenase, MMP1. Eclética Química, 34(4), 87–102. https://doi.org/10.26850/1678-4618eqj.v39.4.2009.p87-102

Abstract

Different common drugs (Meloxicam, Tenoxicam and Piroxicam, and sodium alendronate) were tested both experimental and theoretically as inhibitors of interstitial human collagenase, also known as matrix metalloproteinase 1 (MMP-1). The in vitro collagenase activity, alone and in the presence of inhibitors, was quantified by the reaction with a fluorescent synthetic substrate and measuring the change of emission. Collagenase-inhibitor interaction was studied theoretically by computational calculations. Three among the four tested substances showed moderate inhibiting activity against the human collagenase.
https://doi.org/10.26850/1678-4618eqj.v39.4.2009.p87-102
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