Inhibitors of human collagenase, MMP1

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Published: Dec 21, 2009
DOI: https://doi.org/10.26850/1678-4618eqj.v39.4.2009.p87-102
Keywords:
collagenase, MMP-1, human metalloproteinases, inhibitors, docking

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Sergio Roberto de Andrade Leite
Universidade Estadual Paulista, Instituto de Química, Araraquara, Brasil.

Abstract

Different common drugs (Meloxicam, Tenoxicam and Piroxicam, and sodium alendronate) were tested both experimental and theoretically as inhibitors of interstitial human collagenase, also known as matrix metalloproteinase 1 (MMP-1). The in vitro collagenase activity, alone and in the presence of inhibitors, was quantified by the reaction with a fluorescent synthetic substrate and measuring the change of emission. Collagenase-inhibitor interaction was studied theoretically by computational calculations. Three among the four tested substances showed moderate inhibiting activity against the human collagenase.

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How to Cite
Leite, S. R. de A. (2009). Inhibitors of human collagenase, MMP1. Eclética Química, 34(4), 87–102. https://doi.org/10.26850/1678-4618eqj.v39.4.2009.p87-102
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Vol. 34 No. 4 (2009): Eclética Química
Section
Original articles
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