Antifungal piperamides from Piper mollicomum Kunth (Piperaceae)

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Published: May 29, 2018
DOI: https://doi.org/10.26850/1678-4618eqj.v43.1.2018.p33-38

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Herlle Aparecido da Silva
LAPESB, Department of Instrumental and Basic Studies, State University of Southeast of Bahia, BR 415, Km 03, s/n, 45.700-000 Itapetinga, Bahia
Lydia Fumiko Yamaguchi
Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, SP
http://orcid.org/0000-0003-2305-8208
Maria Cláudia Marx Young
Seção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, CP 3005, 01061-970 São Paulo, SP
http://orcid.org/0000-0002-2860-6659
Clécio Souza Ramos
Departamento de Ciências Moleculares, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, 52171-030 Recife, PE
http://orcid.org/0000-0002-9177-4524
André Márcio Araújo Amorim
Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Rodovia Ilhéus-Itabuna, Km 16, 45662-900 Ilhéus, Bahia
Massuo Jorge Kato
Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, SP
http://orcid.org/0000-0002-3315-2129
Ronan Batista
Departamento de Química Orgânica - Instituto de Química Universidade Federal da Bahia - UFBA Rua Barão de Jeremoabo, s/n, Ondina 40170-115 Salvador - Bahia
http://orcid.org/0000-0003-3401-6054

Abstract

The phytochemical study on dichlorometane extracts of leaves, stem and roots of Piper mollicomum Kunth (Piperaceae) led to isolation of the known piperamides tembamide (1), (R)-(-)-tembamide acetate (2) and riparin I (3). Compounds 1 and 2 displayed moderate in vitro antifungal activity against Cladosporium cladosporioides (5.0 μg) and Cladosporium sphaerospermum (1.0 μg) by direct bioautographic analyses and compound 3 was inactive up to 100.0 μg.

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da Silva, H. A., Yamaguchi, L. F., Young, M. C. M., Ramos, C. S., Amorim, A. M. A., Kato, M. J., & Batista, R. (2018). Antifungal piperamides from Piper mollicomum Kunth (Piperaceae). Eclética Química, 43(1), 33–38. https://doi.org/10.26850/1678-4618eqj.v43.1.2018.p33-38
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Vol. 43 No. 1 (2018): Eclética Química Journal
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Original articles
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