Spectrophotometric flow injection system for determination of Zn2+ in ophthalmic formulations using Alizarin red S

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Published: Nov 20, 2009
DOI: https://doi.org/10.26850/1678-4618eqj.v34.2.2009.p67-72
Keywords:
flow injection analysis, zinc(II), Alizarin red S, spectrophotometry, ophthalmic formulations

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Orlando Fatibello-Filho
Universidade Federal de São Carlos, Centro de Ciências Exatas e de Tecnologia, São Carlos, Brasil.
https://orcid.org/0000-0002-6923-2227
Heberth Juliano Vieira
Universidade do Pampa, Centro de Ciências Exatas e Tecnológicas, Bagé, Brasil.
https://orcid.org/0000-0002-4917-8825

Abstract

A spectrophotometric flow injection method for the determination of Zn(II) in ophthalmic formulations was developed. In this work, Zn(II) ion was complexed with Alizarin red S in borate buffer solution (pH 9.0) and the chromophore produced was monitored at 520 nm. The analytical curve was linear in the Zn(II) concentration range from 6.05 x 10-6 to 1.50 x 10-4 mol L-1 with a detection limit of 3.60 x 10-6 mol L-1. Recoveries ranged from 96.3 to 105 % and a relative standard deviation of 1.2 % (n = 10) for 5.5x10-5 mol L-1 Zn(II) reference solution were obtained. The sampling rate was 60 h-1 and the results obtained of Zn(II) in ophthalmic products using this procedure are in close agreement with those obtained using a comparative spectrophotometric procedure at 95 % confidence level.

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How to Cite
Fatibello-Filho, O., & Vieira, H. J. (2009). Spectrophotometric flow injection system for determination of Zn2+ in ophthalmic formulations using Alizarin red S. Eclética Química, 34(2), 67–72. https://doi.org/10.26850/1678-4618eqj.v34.2.2009.p67-72
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Vol. 34 No. 2 (2009): Eclética Química
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Original articles
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