Spectrophotometric flow injection system for determination of Zn2+ in ophthalmic formulations using Alizarin red S
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Keywords

flow injection analysis
zinc(II)
Alizarin red S
spectrophotometry
ophthalmic formulations

How to Cite

Fatibello-Filho, O., & Vieira, H. J. (2009). Spectrophotometric flow injection system for determination of Zn2+ in ophthalmic formulations using Alizarin red S. Eclética Química, 34(2), 67–72. https://doi.org/10.26850/1678-4618eqj.v34.2.2009.p67-72

Abstract

A spectrophotometric flow injection method for the determination of Zn(II) in ophthalmic formulations was developed. In this work, Zn(II) ion was complexed with Alizarin red S in borate buffer solution (pH 9.0) and the chromophore produced was monitored at 520 nm. The analytical curve was linear in the Zn(II) concentration range from 6.05 x 10-6 to 1.50 x 10-4 mol L-1 with a detection limit of 3.60 x 10-6 mol L-1. Recoveries ranged from 96.3 to 105 % and a relative standard deviation of 1.2 % (n = 10) for 5.5x10-5 mol L-1 Zn(II) reference solution were obtained. The sampling rate was 60 h-1 and the results obtained of Zn(II) in ophthalmic products using this procedure are in close agreement with those obtained using a comparative spectrophotometric procedure at 95 % confidence level.
https://doi.org/10.26850/1678-4618eqj.v34.2.2009.p67-72
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References

C.P. Gonçalves, Oftalmologia, São Paulo, Livraria Atheneu,

J.J. Zeelie, T.J. McCarthy, Analyst 123 (1998) 503.

USP, United States Pharmacopeial XXII, Rockville, MD,

U.S Pharmacopeial Convention, 1990.

A. Bhalotra, B.K. Puri, Talanta 49 (1999) 485.

Shrirama, V.N. Pathak, I.C. Shukla, Chem. Anal-Warsaw

(1980) 91.

S. Zareba, Pharmaceutical Acta Helvetica 70 (1995) 195.

J. Karpinska, M. Kulikowska, J. Pharm. Biomed. Anal. 29 (2002) 153.

O.C. Manouri, N.D. Papadimas, S.E. Salta, G.C. Ragos,

M.A. Demertzis, P.B. Issopoulos, Farmaco 53 (1998) 563.

G. Gumus, H. Filik, B. Demirata, Anal. Chim. Acta 547

(2005) 138.

J. Raba, C.A. Fontan, V.A. Cortinez, Talanta 41 (1994)

R. Fakhari, M. Shamsipur, K. Ghanbari, Anal. Chim. Acta 460 (2002) 177.

M.B. Gholivand, Y. Mozaffari, Talanta 59 (2003) 399.

F. Lo-Coco, L. Ceccon, L. Ciraolo, V. Novelli, Food Control 14 (2003) 55.

E. Muñoz, S. Palmero, Food Chemistry 94 (2006) 478.

M.F.d. Oliveira, A.A. Saczk, L.L. Okumura, N.R. Stradiotto, Ecl. Quim. 27 (2002) 153.

M.I. Albero, J.A. Ortuño, M.S. García, C. Sáchez-Pedreño,

R. Expósito, J. Pharm. Biomed. Anal. 29 (2002) 779.

M.J. Ayora-Cañada, M.I. Pascual-Reguera, A. Molina-Díaz, Anal. Chim. Acta 375 (1998) 71.

R. Liu, D. Liu, A. Sun, Talanta 40 (1993)

L.S.G. Teixeira, F.R.P. Rocha, M. Korn, B.F. Reis, S.L.C.

Ferreira, A.C.S. Costa, Talanta 51 (2000) 1027.

S. Suteerapataranon, J. Jakmunee, Y. Vaneesorn, K. Grudpan, Talanta 58 (2002) 1235.

L. Yuanqian, H. Jingmei, Y. Jingguo, Z. Bo, H. Yuanqing,

Anal. Chim. Acta 461 (2002) 181.

M. Burguera-Pascu, A. Rodríguez-Archilla, J.L. Burguera,

M. Burguera, C. Rondón, P. Carrero, Anal. Chim. Acta 600 (2007) 214.

F.R.P. Rocha, P.B. Martelli, B.F. Reis, Anal. Chim. Acta

(2001) 11.

K. Ueno, T. Imamura, L. Cheng, Handbook of Organic

Analytical Reagents, 2, London, CRC Press, 1992.

H. Bergamin-Filho, E.A.G. Zagatto, F.J. Krug, B.F. Reis,

Anal. Chim. Acta 101 (1978) 17.

J. Mendham, Vogel’s Quantitative Chemical Analysis, 6th Edition, New York, Longman.

R. Patel, K.S. Patel, Talanta 48 (1999) 923.

J.C. Miller, J.N. Miller, Estadística para Química Analítica,

Delaware, Addison-Wesley Iberoamericana S.A., 1993.

O.C. Manouri, N.D. Papadimas, S.E. Salta, G.C. Ragos,

M.A. Demertzis, P.B. Issopoulos, Farmaco 53 (1998) 563.

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