A simple spectrophotometric method for the determination of captopril in pharmaceutical preparations using ammonium molybdate

Main Article Content

Paulo Roberto da Silva Ribeiro
Leonardo Pezza
Helena Redigolo Pezza

Abstract

A simple, rapid and sensitive spectrophotometric method for the determination of captopril (CPT) in pharmaceutical formulations is proposed. This method is based on the reduction reaction of ammonium molybdate, in the presence of sulphuric acid, for the group thiol of CPT, producing a green compound (λmax 407 nm). Beer’s law is obeyed in a concentration range of 4.60 x 10-4 – 1.84 x 10-3 mol l-1 of CPT with an excellent correlation coefficient (r = 0.9995). The limit of detection and limit of quantification were 7.31 x 10-6 e 2.43 x 10-5 mol l-1 of CPT, respectively. The proposed method was successfully applied to the determination of CPT in commercial brands of pharmaceuticals. No interferences were observed from the common excipients in the formulations. The results obtained by the proposed method were favorably compared with those given by the official reported method at 95 % confidence level.

Metrics

Metrics Loading ...

Article Details

How to Cite
Ribeiro, P. R. da S., Pezza, L., & Pezza, H. R. (2010). A simple spectrophotometric method for the determination of captopril in pharmaceutical preparations using ammonium molybdate. Eclética Química, 35(3), 179–188. https://doi.org/10.26850/1678-4618eqj.v35.3.2010.p179-188
Section
Original articles

References

K. Fiorey, Analytical Profiles of Drugs Substances, vol. 11, Academic Press, New York, 1982, p. 81.

A.G. Gilman, J.G. Hardman, L.E. Limbird, P.B. Molinoff, R.W. Ruddon (Eds.), The Pharmacological Basis of Therapeutics, 9th edn., MacGraw-Hill, New York, 1996, p.616.

R.S. Guerrero, S.S. Vives, J.M. Calatayud, Microchem. J.,

(3) (1991) 176.

X.R. Zhang, W.R.G. Baeyens, G. Van Der Weken, A.C.

Calokerinos, K. Nakashima, Anal. Chim. Acta 303 (1995) 121.

Z.D. Zhang, W.R.G. Baeyens, X.R. Zhang, T. Van Der Weken, J. Pharm. Biomed. Anal. 14 (8-10) (1996) 939.

Z. Xinrong, W.R.G. Baeyens, G. Van Der Weken, A.C.

Calokerinos, K. Nakashima, J. Pharm. Biomed. Anal. 13 (1995) 425.

A. Economou, D.G. Themelis, G. Theodoridis, P.D. Tzanavaras, Anal. Chim. Acta 463 (2002) 249.

A.F.M. El Walily, O.A. Razak, S.F. Belal, R.S. Bakry, J.

Pharm. Biom. Anal. 21 (1999) 439.

M.A. El Reis, F.M. Abou Attia, I.M.M. Kenawy, J. Pharm.

Biom. Anal. 23 (2000) 249.

T. Mirza, H.S.I. Tan, J. Pharm. Biomed. Anal. 25 (2001)

R.J. Kok, J. Visser, F. Moolenaar, D. Zeeuw, D.K.F. Meijer, J. Chromatogr. B 693 (1) (1997) 181.

A. Jankowski, A. Skorek, K. Krzyr ko, P.K. Zarzycki,

R.J. Ochocka, H. Lamparczyk, J. Pharm. Biomed. Anal. 13

(1995) 655.

S. Sypniewski, E. Bald, J. Chromatogr. A 729 (1996) 335.

E. Bald, S. Sypniewski, Fresenius J. Anal. Chem. 358 (4) (1997) 554.

V. Cavrini, R. Gatti, A.M. Dipreta, M.A. Raggi, Chromatographia 23 (9) (1987) 680.

V. Cavrini, R. Gatti, V. Andrisano, R. Gatti, Chromatographia 42 (9-10) (1996) 515.

G. Favaro, M. Fiorani, Anal. Chim. Acta 332 (2-3) (1996) 249.

Y.C. Liu, H.L. Wu, H.S. Kou, S.H. Chen, S.M. Wu, Anal.

Lett. 28 (8) (1995) 1465.

J.H.G. Fraga, A.I.J. Abizanda, F.J. Moreno, J.J.A. Leon,

Talanta 46 (1) (1998) 75.

R.I. Stefan, J.K.F. Van Staden, H.Y. Aboul-Enein, Anal.

Chim. Acta 411 (2000) 51.

M.E. Palomeque, B.S.F. Band, J. Pharm. Biomed. Anal.

(3) (2002) 547.

M.E. Mohamed, M. E., Aboul – Enein, H.Y, Anal. Lett.

(B20) (1985) 2591.

United States Pharmacopeial Convention, The United

States Pharmacopeia: The national formulary: captopril, 24th

edn., Revision. Rockville, 2000, p. 296.

M.E. Mohamed, H.Y. Aboul-Enein, E.A. Gad-Kariem,

Anal. Lett. 16 (B1) (1983) 45.

A.M. El-Brashy, Acta Pharm. Hung. 65 (3) (1995) 91.

[26] R.I. Stefan, J.F. Van Staden, H.Y. Aboul–Enein,

Talanta 48 (5) (1999) 1139.

A.M. Pimenta, A.N. Araújo, M.C.B.S.M. Montenegro,

Anal. Chim. Acta 438 (2001) 31.

P.R.S. Ribeiro, A.O. Santini, H.R. Pezza, L. Pezza, Eclét.

Quim. 28 (1) (2003) 39.

S. Hillaert, W. Van Den Bossche, J. Pharm. Biomed.

Anal. 21 (1) (1999) 65.

K. Nikolic, K. S. Valasevic, Pharmazie 44 (2) (1989) 155.

K. Nikolic, K.S. Valasevic, Acta Pol. Pharm. 48 (1 – 2)

(1991) 5.

K. Sarna, Z. Fijalek, Chem. Anal. (Warsaw) 42 (3) (1997) 425.

Ribeiro, P.R.S.; Santini, A.O.; Pezza, H.R.; Pezza, L.;

Eclet. Quim. 2003, 28, 39.

H.F. Askal, Talanta 10 (1991) 1155.

F.M. Ashour, F.M. Salama, M.A.E. Aziza, J. Drugs Res. 19 (1-2) (1990) 323.

M. I. Albero, C. Sánchez-Petreño, M. S. Garciá, V. Ródenas, J. Pharma. Biom. Anal. 11 (1993) 887.

T. Jovanivic, B. Stanovic, Z. Koricanac, J. Pharm. Biomed. Anal. 13 (3) (1995) 213.

P.D. Tzanavaras, D.G. Themelis, A. Economou, G.

Theodoridis, Talanta, 57 (2002) 575.

N.M. Sanghavi, M.M. Samarth, R. Matharu, P.S. Indian

Drugs 28 (4) (1991) 189.

C.S.P. Sastry, A. Sailaja, T.T. Rao, Pharmazie 46 (6)

(1991) 465.

R. Karlicek, P. Solich, Pharmazie 53 (8) (1998) 549.

S. M. El-Ashry, F. A. Ibrahim, Anal. Lett. 25 (9) (1992) 1657.

B. Morelli, P. Peluso, Anal. Lett. 18 (15) (1985) 1865.

S. M. Sultan, Analyst, 111 (1) (1986) 97.

M. M. Abdel Khalek, M. S. Mahrous, Talanta 31 (8) (1984) 635.

P. B. Issopoulos, J. Pharm. Biomed. Anal. 6 (1) (1988) 97.

P. B. Issopoulos, Analyst 113 (7) (1988) 1083.

M. Stan, V. Dorneanu, G. Ghimicescu, Talanta 24 (2) (1977) 140.

H. Sanke Gowda, P. G. Ramappa, A. N. Nayak, Anal. Chim. Acta 108 (6) (1979) 277.

P. Timmins, I.M. Jackson, Y.I. Wang, Int. J. Pharm. 11 (4) (1982) 329.

Long, G.L.; Winefordner, J.D.; Anal. Chem. 1983, 55, 712.

J.C. Miller, J.N. Miller, Estadística para Química Analítica, 2nd edn.; Addison-Wesley Iberoamericana, Delaware, E.U.A., 1993, p.209.