Titrimetric assay of lisinopril in aqueous and non-aqueous media

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Published: Jun 28, 2010
DOI: https://doi.org/10.26850/1678-4618eqj.v35.2.2010.p07-14
Keywords:
lisinopril, titrimetry, potentiometry, pharmaceuticals

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Basavaiah Kanakapura
University of Mysore, Department of Chemistry, Mysore, India.
Kalsang Tharpa
University of Mysore, Department of Chemistry, Mysore, India.
Kanakapura Basavaiah Vinay
Advinus Therapeutics Pvt. Ltd., Peenya II Phase, Bangalore, India.

Abstract

Four simple titrimetric procedures are described for the determination of lisinopril (LNP) in bulk and in pharmaceuticals based on the neutralization of basic-amino and acidic carboxylic acid groups present in LNP. Method A is based on the neutralization of basic amino groups using perchloric acid as titrant in anhydrous acetic acid medium. Method B, method C and method D are based on neutralization of carboxylic acid group using NaOH, sodium methoxide and methanolic KOH, as titrants, respectively. Method A is applicable over 2.0-20.0 mg range and the calculations are based in the molar ratio of 1:2 (LNP:HClO4). Method B, method C and method D are applicable over 2.0-20.0 mg, 1.0-10.0 mg and 5.0-15.0 mg range,  respectively, and their respective molar ratios are 1:1 (LNP:NaOH), 1:2 (LNP:CH3ONa) and 1:1 (LNP:KOH). Intraday and inter day accuracy and precision of the methods were evaluated and the results showed intra- and inter-day precision less than 2.7% (RSD), and accuracy of < 2.5% (RE). The developed methods were applied to determine LNP in tablets and the results were validated statistically by comparing the results with those of the reference method by applying the Student’s t-test and F-test.

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How to Cite
Kanakapura, B., Tharpa, K., & Vinay, K. B. (2010). Titrimetric assay of lisinopril in aqueous and non-aqueous media. Eclética Química, 35(2), 07–14. https://doi.org/10.26850/1678-4618eqj.v35.2.2010.p07-14
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Vol. 35 No. 2 (2010): Eclética Química
Section
Original articles
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References

Parfitt, K. “The Complete Drug Reference”. (1999) 32nd

ed. 898. The Pharamaceutical Press, Martindalle, MA.

The British Pharmacopoeia, Her Majesty’s Stationary Office, London, (1998) pp. 799.

The US Pharmacopoeia, 24th revision, Asian Edition, United States Pharmacopoeial Convention, INC, Twinbrook Parkway, Rockville, MD, (2000), pp. 979 and pp. 2149.

G. Parashevas, J. Atta-Politou, M. Koupparis, J. Pharm. Biomed. Anal 8 (2002) 865.

A. Rajasekaran, S. Udayavani, J Indian Chem Soc., 78 (2001) 485.

F.A El-Yazbi, H.H. Abdine, R.A. Shaalan, J. Pharm. Biomed. Anal, 19 (1999) 819.

A. El-Gindy, A. Ashour, L. Abdel-Fattah, M.M. Shabana, J. Pharm. Biomed. Anal 25 (2001) 923.

N. Rahman, N. Anwar, M. Kashif, Farmaco 60 (2005) 605.

R. Asad, M.A. Tariq, U.R. Atta, J. Chin. Chem. Soc 52 (2005) 1055.

R. Nafisur, S. Manisha, H. Md. Nasrul, J. Braz. Chem. Soc 16 (2005) 1001.

N. Rahman, M.R. Siddiqui, S.N.H. Azmi, Chem. Anal. (Warsaw) 52 (2007) 465.

O. Abdel Razak, S.F. Belal, M.M. Bedair, N.S. Barakat, R.S. Haggag, J. Pharm. Biomed. Anal 31 (2003) 701-711.

S.A. Esra, E. Lale, S. Olcay, II Farmaco 58 (2003)165. [14] C. Zacharis, P. Tzanavaras, , D. Themelis, , G. Theodoridis, , A. Economou, P. Rigas, Anal. Bioanal. Chem 379 (2004) 759.

O. Durisehvar, S. Hulya, J. Pharm. Biomed. Anal. 21(1999) 691.

A. El-Gindy, A. Ashour, L. Abdel-Fattah, M.M. Shabana, J. Pharm. Biomed. Anal 25 (2001) 923.

S. Beata, Acta. Pol. Pharm 61 (2005) 327.

D. Bonazzi, R. Gotti, V. Andrisano, V. Cavrini, J. Pharm. Biomed. Anal 16 (1997) 431.

C.V.N. Prasad, R.N. Saha, P. Parimoo, Pharm. Pharmacol. Commun 5 (1999) 383.

D. Ozer, H. Senel, J. Pharm. Biomed. Anal 21 (1999) 691.

R.C. Mashru, P.P. Parikh, East. Pharm 43 (2000)111.

H.K. Jain, R.K. Agrawal, Indian Drugs 37 (2000) 196.

N. Erk, Spectrosc-Lett., 31 (1998) 633.

N. El-Enany, F. Belal, S. Al-Ghannam, Mikrochim. Acta 141 (2003) 55.

A. Rajasekaran, S. Murugesan, Asian J. Chem 13 (2001) 1245.

A.B. Avadhanulu, A.R.R. Pantulu, Indian Drugs 30 (1993) 646.

S. Hillaert, K. De Grauwe, and B.W. Van den, J. Chromatogr. A 924 (2001) 439.

D. Ivanoic, M. Medenica, B. Jancic, N. Knezevic, Acta Chromatogr 18 (2007) 143.

E.R.K. Nevin, K. Murat, Ana. Lett 32 (1999) 1131.

R.T. Sane, G.R. Valiyare, U.M. Deshmukh, S.R. Singh, R. Sodhi, Indian Drugs 29 (1992) 558.

A.B. Christopher, S. Jessica, Z. Zack, A.R. Robert, J. Pharm. Biomed. Anal 37 (2004) 559.

S.S.M. Hassan, M.B. Elsayes, Mikrochimica Acta (1973) 801-807.

J.S. Fritz and R.T. Keen, Anal. Chem 25 (1953)179-181.

J.S. Firtz and N.M. Lisicki, Anal. Chem 23 (1951) 589.

J. Firtz. Anal. Chem 24 (1952) 306.

International Conference on Hormonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonised Tripartite Guideline, Validation of Analytical Procedures: Text and ethodology Q2(R1), Complementary Guideline on Methodology dated 06

November 1996, incorporated in November 2005, London.