Keywords
chromotropic acid
diphenylamine
spectrophotometry
pharmaceutical analysis
How to Cite
Abstract
Two simple and sensitive spectrophotometric methods (M 1 and M 2 ) for the determination ofmosapride in pure and in pharmaceutical preparations are described. These methods are based on the
interaction of diazotized mosapride (MSP) couples with chromotropic acid (CTA) [M 1 ] in alkaline
medium and diphenylamine (DPA) [M 2 ] in acidic medium. The resulting azo-dyes exhibit maximum
absorption at 560 nm and at 540 nm for methods M 1 and M 2 , respectively. All variables were studied
in order to optimize the reaction conditions. No interferences were observed from excipients, and the
validity of the each method was tested against reference method.
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