Desenvolvimento e validação de método analítico espectrofotométrico para quantificação de nerolidol em um dispositivo polimérico de liberação prolongada, após derivatização com vanilina
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Keywords

Nnerolidol
Quitosan
Spectrometric method for alcohols and lipids

How to Cite

Ribeiro, T. G., Franca, J. R., Marques, A. M., Coelho Kaplan, M. A., Faraco, A. A. G., & Castilho, R. O. (2014). Desenvolvimento e validação de método analítico espectrofotométrico para quantificação de nerolidol em um dispositivo polimérico de liberação prolongada, após derivatização com vanilina. Eclética Química, 37(1), 61–67. https://doi.org/10.26850/1678-4618eqj.v37.1.2012.p61-67

Abstract

This work describes the development and validation of analytical method to assay nerolidol in a hydrophilic matrix of quitosan by UV/visible spectroscopy. The method is based on the formation of purple derivative between nerolidol and vanillin. The validated method was linear (2.5 - 50 mg mL-1, concentration range, r > 0.99), precise (RSD 0.44% for repeatability and 0.32% for intermediate precision), accurate (100.04% recovery), robust and specific. Detection and quantitation limits were 0.74 mg mL-1 and 2.26 mg mL-1, respectively. The method is simple and fast and it was applied successfully. Alternatively, the described method may be applied for the analysis of alcohols and unsaturated lipids.

https://doi.org/10.26850/1678-4618eqj.v37.1.2012.p61-67
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2017 Eclética Química Journal

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