Campomanesia genus – a literature review of nonvolatile secondary metabolites, phytochemistry, popular use, biological activities, and toxicology

Luiza de Souza Duarte, Mariana Toledo Martins Pereira, Vinicius D’Ávila Bitencourt Pascoal, Aislan Cristina Rheder Fagundes Pascoal

Abstract


The genus Campomanesia belongs to the Myrtaceae family and has about 30 species. It is characterized by citrus-flavored fruits. Several articles describe the extensive use of its fruit, such as in the food industry, however, other parts of the plants are also used for food or pharmacological purposes such as the leaves, flowers, seeds, and roots. Analyzing works published on the genus in the period 2005-2019, we observed that the classes of main flavonoid compounds present are anthocyanins, chalcones, coumarins, tannins, and saponins. Species of this genus are also used as a medicine in the treatment of wounds, toothaches, fractures, and bruises.  Therapeutic activities have also been detected for Campomanesia, such as antimicrobial, antiulcerogenic, antiprotozoal, anti-inflammatory, and antidiarrheal activity, antiproliferative and antioxidant potential, antiplatelet, antithrombotic, and fibrinolytic activities, as well as hypotensive effects. There are a small number of works demonstrating the low toxic potential of plant extracts. Thus, the Campomanesia genus presents pharmacological potential to be explored.


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References


Brandão, H. N., David, J. P., Couto, R. D., Nascimento, J. A. P., David, J. M., Química e Farmacologia de Quimioterápicos Antineoplásicos Derivados de Plantas, Química Nova 33 (6) (2010) 1359-1369. https://doi.org/10.1590/S0100-40422010000600026.

Borchardt, J. K., The Beginnings of Drug Therapy: Ancient Mesopotamian Medicine, Drug News & Perspectives 15 (3) (2002) 187-192. https://doi.org/10.1358/dnp.2002.15.3.840015.

Newman, D. J., Cragg, G. M., Natural Products as Sources of New Drugs from 1981 to 2014, Journal of Natural Products 79 (3) (2016) 629-661. https://doi.org/10.1021/acs.jnatprod.5b01055.

Ríos, J. L., Recio, M. C., Medicinal plants and antimicrobial activity, Journal of Ethnopharmacology 100 (1-2) (2005) 80-84. https://doi.org/10.1016/j.jep.2005.04.025.

Sahib, N. G., Saari, N., Ismail, A., Khatib, A., Mahomoodally, F., Hamid, A. A., Plants' Metabolites as Potential Antiobesity Agents, The Scientific World Journal 2012 (436039) (2012) 1-8. https://doi.org/10.1100/2012/436039.

The Plant List., Myrtaceae, The Plant List: A working list of all plant species (2018). http://www.theplantlist.org/1.1/browse/A/Myrtaceae.

Wilson, P. G., O’Brien, M. M., Gadek, P. A., Quinn, C. J., Myrtaceae revisited: A reassessment of infrafamilial groups, American Journal of Botany 88 (11) (2001) 2013-2025. https://doi.org/10.2307/3558428.

Conti, E., Litt, A., Wilson, P. G., Graham, S. A., Briggs, B. G., Johnson, L. A. S., Sytsma, K. J., Interfamilial relationships in Myrtales: molecular phylogeny and patterns of morphological evolution, Systematic Botany 22 (4) (1997) 629-647. https://doi.org/10.2307/2419432.

Landrum, L. R., Campomanesia, Pimenta, Blepharocalyx, Legrandia, Acca, Myrrhinium e Luma (Myrtaceae), In: Flora Neotropica, The New York Botanical Garden: New York, United States of America, 1986, ch2.

Silva, C. A. de A., Fonseca, G. G., Brazilian savannah fruits: Characteristics, properties, and potential applications, Food Science and Biotechnology 25 (5) (2016) 1225-1232. https://doi.org/10.1007/s10068-016-0195-3.

Vogt, T., Phenylpropanoid Biosynthesis, Molecular Plant 3 (1) (2010) 2-20. https://doi.org/10.1093/mp/ssp106.

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., Shimomura, I., Increased oxidative stress in obesity and its impact on metabolic syndrome, The Journal of Clinical Investigation 114 (12) (2017) 1752-1761. https://doi.org/10.1172/JCI21625.

Klafke, J. Z., Silva, M. A. da, Panigas, T. F., Belli, K. C., Oliveira, M. F. de, Barichello, M. M., Rigo, F. K., Rossato, M. F., Santos, A. R. S. dos, Pizzolatti, M. G., Ferreira, J., Viecili, P. R. N., Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients, Journal of Ethnopharmacology 127 (2-3) (2010) 299-305. https://doi.org/10.1016/j.jep.2009.11.004.

Sant'Anna, L. S., Merlugo, L., Ehle, C. S., Limberger, J., Fernandes, M. B., Santos, M. C., Mendez, A. S. L., Paula, F. R., Moreira, C. M., Chemical composition and hypotensive effect of Campomanesia xanthocarpa, Evidence-Based Complementary and Alternative Medicine 2017 (1591762) (2017) 1-11. https://doi.org/10.1155/2017/1591762.

Espindola, P., da Rocha, P., Carollo, C., Schmitz, W., Pereira, Z., Vieira, M., dos Santos, E., Souza, K., Antioxidant and antihyperlipidemic effects of Campomanesia adamantium O. Berg Root, Oxidative Medicine and Cellular Longevity 2016 (7910340) (2016) 1-8. https://doi.org/10.1155/2016/7910340.

Alves, A. M., Dias, T., Hassimotto, N. M. A., Naves, M. M. V., Ascorbic acid and phenolic contents, antioxidant capacity and flavonoids composition of Brazilian Savannah native fruits, Food Science and Technology 37 (4) (2017) 564-569. https://doi.org/10.1590/1678-457x.26716.

Duarte, W. F., Dias, D. R., Pereira, G. V. de M., Garvásio, I. M., Schwan, R. F., Indigenous and inoculated yeast fermentation of gabiroba (Campomanesia pubescens) pulp for fruit wine production, Journal of Industrial Microbiology & Biotechnology 36 (4) (2009) 557-569. https://doi.org/10.1007/s10295-009-0526-y.

Cardoso, C. A. L., Salmazzo, G. R., Honda, N. K., Prates, C. B., Vieira, M. do C., Coelho, R. G., Antimicrobial activity of the extracts and fractions of hexanic fruits of Campomanesia species (Myrtaceae), Journal of Medicinal Food 13 (5) (2010) 1273-1276. https://doi.org/10.1089/jmf.2009.0047.

Cardoso, C. A. L., Salvador, M. J., Carvalho, J. E., Coelho, R. G., Avaliação das atividades antiproliferativa e antioxidante em frutos de Campomanesia pubescens/Evaluation of antioxidant and antiproliferative activities in fruits of Campomanesia pubescens, Revista Instituto Adolfo Lutz 72 (4) (2013) 309-315. https://pesquisa.bvsalud.org/portal/resource/pt/lil-742458.

Catelan, T. B. S., Radai, J. A. S., Leitão, M. M., Branquinho, L. S., Vasconcelos, P. C. de P., Heredia-Vieira, S. C., Kassuya, C. A. L., Cardoso, C. A. L., Evaluation of the toxicity and anti-inflammatory activities of the infusion of leaves of Campomanesia guazumifolia (Cambess.) O. Berg, Journal of Ethnopharmacology 226 (2018) 132-142. https://doi.org/10.1016/j.jep.2018.08.015.

Nesello, L. Â. N., Campos, A., Wagner, T., Feliciano, A. S., Buzzi, F. de C., Cechinel Filho, V., Chemical composition and antinociceptive potential of Campomanesia reitziana fruits, Journal of Medicinal Food 19 (5) (2016) 518-520. https://doi.org/10.1089/jmf.2015.0092.

Bonilla, A., Duque, C., Garzón, C., Takaishi, Y., Yamaguchi, K., Hara, N., Fujimoto, Y., Champanones, yellow pigments from the seeds of champa (Campomanesia lineatifolia), Phytochemistry. 66 (14) (2005) 1736-1740. https://doi.org/10.1016/j.phytochem.2005.05.025.

Osorio, C., Alarcon, M., Moreno, C., Bonilla, A., Barrios, J., Garzón, C., Duque, C., Characterization of odor-active volatiles in champa (Campomanesia lineatifolia R. & P.), Journal of Agricultural and Food Chemistry 54 (2) (2006) 509-516. https://doi.org/10.1021/jf052098c.

Stefanello, M. E. A., Pascoal, A. C. R. F., Salvador, M. J., Essential oils from neo-tropical Myrtaceae: chemical diversity and biological properties, Chemistry & Biodiversity 8 (1) (2011)73-94. https://doi.org/10.1002/cbdv.201000098.

Pascoal, A. C. R. F., Lourenço, C. C., Sodek, L., Tamashiro, J. Y., Franchi Junior, G. C., Nowill, A. E., Stefanello, M. É. A., Salvador, M. J., Essential oil from the leaves of Campomanesia guaviroba (DC.) Kiaersk. (Myrtaceae): chemical composition, antioxidant and cytotoxic activity, Journal of Essential Oil Research 23 (5) (2011) 34-37. https://doi.org/10.1080/10412905.2011.9700479.

Kumar, G., Karthik, L., Rao, K. V. B., Haemolytic activity of Indian medicinal plants toward human erythrocytes: an in vitro study, Elixir International Journal Applied Botany 40 (2011) 5534-5537. https://www.elixirpublishers.com/articles/1350647393_40%20(2011)%205534-5537.pdf.

Vieira, R. F., Costa, T. da S. A., Silva, D. B. da, Ferreira, F. R., Sano, S. M., Frutas nativas da região Centro-Oeste, Embrapa Recursos Genéticos e Biotecnologia, Brasília, 2006. http://www.agabrasil.org.br/_Dinamicos/livro_frutas_nativas_Embrapa.pdf.

Carvalho, P. E. R., Espécies arbóreas brasileiras. Coleção Espécies Arbóreas Brasileiras, Embrapa informações Tecnológica, Brasília, 2006, v2. https://livimagens.sct.embrapa.br/amostras/00079500.pdf.

Alice, C. B., Plantas medicinais de uso popular: atlas farmacognóstico, Canoas, 1995, 205 p.

Guerrero, F. M. G., Zimmerman, L. R., Cardoso, E. V., Lima, C. A. C. de, Perdomo, R. T., Alva, R., Carollo, C. A., Guerrero, A. T., Investigação sobre a toxicidade crônica de folhas de guavira (Campomanesia pubescens) em ratos machos, Revista Fitos 5 (2) (2013) 64-72. https://www.arca.fiocruz.br/handle/icict/19179.

Araújo, M. C. de P. M., Barcellos, N. M. S., Vieira, P. M. de A., Gouveia, T. M., Guerra, M. O., Peters, V. M., Saúde-Guimarães, D. A., Acute and sub chronic toxicity study of aqueous extract from the leaves and branches of Campomanesia velutina (Cambess) O. Berg, Journal of Ethnopharmacology 201 (2017) 17-25. https://doi.org/10.1016/j.jep.2017.02.043.

Alam, M. N., Bristi, N. J., Rafiquzzaman, M., Review on in vivo and in vitro methods evaluation of antioxidant activity, Saudi Pharmaceutical Journal 21 (2) (2013) 143-152. https://doi.org/10.1016/j.jsps.2012.05.002.

Pavan, F. R., Leite, C. Q. F., Coelho, R. G., Coutinho, I. D., Honda, N. K., Cardoso, C. A. L., Vilegas, W., Leite, S. R. de A., Sato, D. N., Evaluation of anti Mycobacterium tuberculosis activity of Campomanesia adamantium (Myrtaceae), Química Nova 32 (5) (2009) 1222-1226. https://doi.org/10.1590/S0100-40422009000500026.

Brandelli, C. L. C., Vieira, P. de B., Macedo, A. J., Tasca, T., Remarkable Anti-Trichomonas vaginalis activity of plants traditionally used by the Mbyá-Guarani indigenous group in Brazil, BioMed Research International 2013 (826370) (2013) 1-7. https://doi.org/10.1155/2013/826370.

Sandhar, H. K., Kumar, B., Prasher, S., Tiwari, P., Salhan, M., Sharma, P., A review of phytochemistry and pharmacology of flavonoids, Internationale Pharmaceutica Sciencia 1 (1) (2011) 25-41.

Moura-Costa, G. F., Nocchi, S. R., Ceole, L. F., Mello, J. C. P. de, Nakamura, C. V., Dias Filho, B. P., Temponi, L. G., Ueda-Nakamura, T., Antimicrobial activity of plants used as medicinals on an indigenous reserve in Rio das Cobras, Paraná, Brazil, Journal of Ethnopharmacology 143 (2) (2012) 631-638. https://doi.org/10.1016/j.jep.2012.07.016.

Markman, B. E. O., Bacchi, E. M., Kato, E. T. M., Antiulcerogenic effects of Campomanesia xanthocarpa, Journal of Ethnopharmacology 94 (1) (2004) 55-57. https://doi.org/10.1016/j.jep.2004.04.025.

Silva, É. R. S. da, Salmazzo, G. R., Arrigo, J. da S., Oliveira, R. J., Kassuya, C. A. L., Cardoso, C. A. L., Anti-inflammatory evaluation and toxicological analysis of Campomanesia xanthocarpa Berg, Inflammation 39 (4) (2016) 1462-1468. https://doi.org/10.1007/s10753-016-0378-3.

Souza-Moreira, T. M., Salvagnini, L. E., Santos, E., Silva, V. Y. A., Moreira, R. R. D., Salgado, H. R. N., Pietro, R. C. L. R., Antidiarrheal activity of Campomanesia xanthocarpa fruit, Journal of Medicinal Food 14 (5) (2011) 528-531. https://doi.org/10.1089/jmf.2009.0278.

Pereira, M. C., Steffens, R. S., Jablonski, A., Hertz, P. F., Rios, A. de O., Vizzotto, M., Flôres, S. H., Characterization and antioxidant potential of brazilian fruits from the myrtaceae family, Journal of Agricultural and Food Chemistry 60 (12) (2012) 3061-3067. https://doi.org/10.1021/jf205263f.

Klafke, J. Z., Silva, M. A. da, Rossato, M. F., Trevisan, G., Walker, C. I. B., Leal, C. A. M., Borges, D. O., Schetinger, M. R. C., Moresco, R. N., Duarte, M. M. M. F., Santos, A. R. S. dos, Viecili, P. R. N., Ferreira, J., Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa, Evidence-Based Complementary and Alternative Medicine 2012 (954748) (2012) 1-8. https://doi.org/10.1155/2012/954748.

Otero, J. S., Hirsch, G. E., Klafke, J. Z., Porto, F. G., Almeida, A. S. de, Nascimento, S., Schmidt, A., Silva, B. da, Pereira, R. L. D., Jaskulski, M., Parisi, M. M., Guarda, N. dos S., Moresco, R. N., Aita, C. A. M., Viecili, P. R. N., Inhibitory effect of Campomanesia xanthocarpa in platelet aggregation: Comparison and synergism with acetylsalicylic acid, Thrombosis Research 154 (2017) 42-49. https://doi.org/10.1016/j.thromres.2017.03.020.

Lima, N. V. de, Arakaki, D. G., Tschinkel, P. F. S., Silva, A. F. da, Guimarães, R. de C. A., Hiane, P. A., Nascimento, V. A. do, Investigation of Campomanesia Components: A Fruit of Brazilian Cerrado, In: Active Ingredients from Aromatic and Medicinal Plants, El-Shemy, H. A., ed., InTech: Houston, United States of America, 2017, Ch. 5. https://doi.org/10.5772/66220.

Lescano, C. H., Oliveira, I. P. de, Zaminelli, T., Baldivia, D. da S., Silva, L. R. da, Napolitano, M., Silvério, C. B. M., Lincopan, N., Sanjinez-Argandoña, E. J., Campomanesia adamantium Peel extract in antidiarrheal activity: the ability of inhibition of heat-stable enterotoxin by polyphenols, Plos One 11 (10) (2016) 1-15. https://doi.org/10.1371/journal.pone.0165208.

Pascoal, A. C. R. F., Ehrenfried, C. A., Lopez, B. G.-C., Araujo, T. M. de, Pascoal, V. D. B., Gilioli, R., Anhê, G. F., Ruiz, A. L. T. G., Carvalho, J. E. de, Stefanello, M. É. A., Salvador, M. J., Antiproliferative activity and induction of apoptosis in PC-3 cells by the chalcone cardamonin from Campomanesia adamantium (Myrtaceae) in a bioactivity-guided study, Molecules 19 (2) (2014) 1843-1855. https://doi.org/10.3390/molecules19021843.

Silva M. C. B. L. e, Bogo, D., Alexandrino, C. A. F., Perdomo, R. T., Figueiredo, P. de O., Prado, P. R. do, Garcez, F. R., Kadri, M. C. T., Ximenes, T. V. N., Guimarães, R. de C. A., Sarmento, U. C., Macedo, M. R. L., Antiproliferative Activity of Extracts of Campomanesia adamantium (Cambess.) O. Berg and Isolated Compound Dimethylchalcone Against B16-F10 Murine Melanoma, Journal of Medicinal Food 21 (10) (2018) 1-11. https://doi.org/10.1089/jmf.2018.0001.

Ferreira, L. C., Grabe-Guimarês, A., Paula, C. A. de, Michel, M. C. P., Guimarães, R. G., Rezende, S. A., Souza Filho, J. D. de, Saúde-Guimarães, D. A., Anti-inflammatory and antinociceptive activities of Campomanesia adamantium, Journal of Ethnopharmacology 145 (9) (2013) 100-108. https://doi.org/10.1016/j.jep.2012.10.037.

Cabral, C. de O., Campos, A., Silva, L. M. da, Boeing, T., Andrade, S. F. de, Cechinel Filho, V., Nesello, L. Â. N., Gastroprotective potential of methanolic extract and dimethyl cardamonin from Campomanesia reitziana fruits in mice, Naunyn-Schmiedeberg's Archives of Pharmacology 390 (6) (2017) 661-666. https://doi.org/10.1007/s00210-017-1369-0.

Madalosso, R. C., Oliveira, G. C., Martins, M. T., Vieira, A. E. D., Barbosa, J., Caliari, M. V., Castilho, R. O., Tagliati, C. A., Campomanesia lineatifolia Ruiz & Pav. as a gastroprotective agente, Journal of Ethnopharmacology 139 (2012) 772-779. https://doi.org/10.1016/j.jep.2011.12.014.

Ekor, M., The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety, Frontiers in Pharmacology 4 (177) (2014) 1-10. https://doi.org/10.3389/fphar.2013.00177.

França, I. S. X. de, Souza, J. A. de, Baptista, R. S., Britto, V. R. de S., Medicina popular: benefícios e malefícios das plantas medicinais, Revista Brasileira de Enfermagem 61 (2) (2007) 201-208. https://doi.org/10.1590/S0034-71672008000200009.

Silveira, P. F. da, Bandeira, M. A. M., Arrais, P. S. D., Farmacovigilância e reações adversas às plantas medicinais e fitoterápicos: Uma realidade, Revista Brasileira de Farmacognosia 18 (4) (2008) 618-626. https://doi.org/10.1590/S0102-695X2008000400021.

Raynor, D. K., Dickinson, R., Knapp, P., Long, A. F., Nicolson, D. J., Buyer beware? Does the information provided with herbal products available over the counter enable safe use? BMC Medicine 9 (94) (2011) 1-8. https://doi.org/10.1186/1741-7015-9-94.

Villas Boas, G. R., Santos, A. C. dos, Souza, R. I. C., Araújo, F. H. S. de, Traesel, G. K., Marcelino, J. M., Silveira, A. P. S. da, Farinelli, B. C. F., Cardoso, C. A. L., Lacerda, R. B. de, Oesterreich, S. A., Preclinical safety evaluation of the ethanolic extract from guavira fruits (Campomanesia pubescens (D.C.) O. BERG) in experimental models of acute and short-term toxicity in rats, Food and Chemical Toxicology 118 (2018) 1-12. https://doi.org/10.1016/j.fct.2018.04.063.

Pastori, T., Flores, F. C., Boligon, A. A., Athayde, M. L., Silva, C. de B. da, Canto-Dorow, T. S. do, Tedesco, S. B., Genotoxic effects of Campomanesia xanthocarpa extracts on Allium cepa vegetal system, Pharmaceutical Biology. 51 (10) (2013) 1249-1255. https://doi.org/10.3109/13880209.2013.786097.

Souza, J. C. de, Piccinelli, A. C., Aquino, D. F. S., Souza, V. V. de, Schmitz, W. O., Traesel, G. K., Cardoso, C. A. L., Kassuya, C. A. L., Arena, A. C., Toxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barks, Nutritional Neuroscience: An International Journal on Nutrition, Diet and Nervous System 20 (1) (2017) 23-31. https://doi.org/10.1179/1476830514Y.0000000145.

Carvalho, A. C. B., Balbino, E. E., Maciel, A., Perfeito, J. P. S., Situação do registro de medicamentos fitoterápicos no Brasil, Revista Brasileira de Farmacognosia 18 (2) (2008) 314-319. https://doi.org/10.1590/S0102-695X2008000200028.

Pascoal, A. C. R. F., Ehrenfried, C. A., Eberline, M. N., Stefanello, M. É. A., Salvador, M. J., Free radical scavenging activity, determination of phenolic compounds and HPLC-DAD/ESI-MS profile of Campomanesia adamantium leaves, Natural Product Communications 6 (7) (2011) 969-972. https://doi.org/10.1177/1934578X1100600711.

Breda, C. A., Gasperini, A. M., Garcia, V. L., Monteiro, K. M., Bataglion, G. A., Eberlin, M. N., Duarte, M. C., Phytochemical analysis and antifungal activity of extracts from leaves and fruit residues of brazilian savanna plants aiming its use as safe fungicides, Natural Products and Bioprospecting 6 (4) (2016) 195-204. https://doi.org/10.1007/s13659-016-0101-y.

Espíndola, P. P. de T., Rocha, P. dos S. da, Carollo, C. A., Schmitz, W. O., Pereira, Z. V., Vieira, M. do C., Santos, E. L. dos, Souza, K. de P., Antioxidant and antihyperlipidemic effects of Campomanesia adamantium O. Berg Root, Oxidative Medicine and Cellular Longevity 2016 (7910340) (2016) 1-8. http://doi.org/10.1155/2016/7910340.

Campos, J. F., Espíndola, P. P. de T., Torquato, H. F. V., Vital, W. D., Justo, G. Z., Silva, D. B., Carollo, C. A., Souza, K. de P., Paredes-Gamero, E. J., Santos, E. L. dos, Leaf and root extracts from Campomanesia adamantium (Myrtaceae) promote apoptotic death of leukemic cells via activation of intracellular calcium and caspase-3, Frontiers in Pharmacology 8 (466) (2017) 1-16. https://doi.org/10.3389/fphar.2017.00466.

Lescano, C. H., Lima, F. F. de, Mendes-Silvério, C. B., Justo, A. F. O., Baldívia, D. da S., Vieira, C. P., Sanjinez-Argandoña, E. J., Cardoso, C. A. L., Mónica, F. Z., Oliveira, I. P. de, Effect of polyphenols from Campomanesia adamantium on platelet aggregation and inhibition of cyclooxygenases: molecular docking and in vitro analysis, Frontiers in Pharmacology 9 (617) (2018) 1-13. https://doi.org/10.3389/fphar.2018.00617.

Villas Boas, G. R., Silveira A. P. S. da, Farinelli, B. C. F., Cardoso, C. A. L., Arce, E., Oesterreich, A. S., The ethanolic extract obtained from Campomanesia pubescens (D.C.) O.BERG fruits exerts anxiolytic and antidepressant effects on chronic mild stress model and on anxiety models in Wistar rats. Behavioral evidences, Nutritional Neuroscience: An International Journal on Nutrition, Diet and Nervous System (2018) 1-11. https://doi.org/10.1080/1028415X.2018.1466513.

Catelan, T. B. S., Brum, C. C. S., Heredia-Vieira, S. C., Crispim, B. A., Grisolia, A. B., Santos, R. C. S., Cardoso, C. A. L., Cytotoxicity, Genotoxicity, Antioxidant Potential and Chemical Composition of Leaves of Campomanesia pubescens (Mart. ex DC.) O.Berg, Current Pharmaceutical Biotechnology 19 (5) (2018) 416-421. https://doi.org/10.2174/1389201019666180626102443.

Villas Boas, G. R., Araújo, F. H. S. de, Marcelino, J. M., Castro, L. H. A., Silveira, A. P. S. da, Nacer, R. S., Souza, F. R. de, Cardoso, C. A. L., Lacerda, R. B. de, Guterres, Z. da D. R., Oesterreich, S. A., Preclinical safety evaluation of the ethanolic extract from Campomanesia pubescens (Mart. ex DC.) O. BERG (guavira) fruits: analysis of genotoxicity and clastogenic effects, Food & Function 9 (7) (2018) 3707-3717. https://doi.org/10.1039/c8fo01017j.

Biavatti, M. W., Farias, C., Curtius, F., Brasil, L. M., Hort, S., Schuster, L., Leite, S. N., Prado, S. R. T., Preliminary studies on Campomanesia xanthocarpa (Berg.) and Cuphea carthagenensis (Jacq.) J.F. Macbr. aqueous extract: weight control and biochemical parameters, Journal of Ethnopharmacology 93 (2-3) (2004) 385-389. https://doi.org/10.1016/j.jep.2004.04.015.

Viecili, P. R. N., Borges, D. O., Kirsten, K., Malheiros, J., Viecili, E., Melo, R. D., Trevisan, G., Silva, M. A. da, Bochi, G. V., Moresco, R. N., Klafke, J. Z., Effects of Campomanesia xanthocarpa on inflammatory processes, oxidative stress, endothelial dysfunction and lipid biomarkers in hypercholesterolemic individuals, Atherosclerosis 234 (1) (2014) 85-92. https://doi.org/10.1016/j.atherosclerosis.2014.02.010.

Brandelli, C. L., Ribeiro, V. B., Zimmer, K. R., Barth, A. L., Tasca, T., Macedo, A. J., Medicinal Plants Used by a Mbyá-Guarani Tribe Against Infections: Activity on KPC-Producing Isolates and Biofilm-Forming Bacteria, Natural Product Communications 10 (11) (2015) 1847-1852. https://doi.org/10.1177/1934578X1501001114.

Schmidt, H. de O., Rockett, F. C., Pagno, C. H., Possa, J., Assis, R. Q., Oliveira, V. R. de, Silva, V. L. da, Flôres, S. H., Rios, A. de O., Vitamin and bioactive compound diversity of seven fruit species from south Brazil, Journal of the Science of Food and Agriculture 99 (7) (2019) 3307-3317. https://doi.org/10.1002/jsfa.9544.

Sousa, J. A. de, Prado, L. D. S., Alderete, B. L., Boaretto, F. B. M., Allgayer, M. C., Miguel, F. M., Sousa, J. T. de, Marroni, N. P., Lemes, M. L. B., Corrêa, D. S., Ferraz, A. B. F., Picada, J. N., Toxicological aspects of Campomanesia xanthocarpa Berg. associated with its phytochemical profile, Journal of Toxicology and Environmental Health, Part A 82 (1) (2019) 62-74. https://doi.org/10.1080/15287394.2018.1562392.




DOI: https://doi.org/10.26850/1678-4618eqj.v45.2.2020.p12-22

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