Abstract
Electrode kinetics and complex formation of Zn(II) using doxycycline, chlortetracycline, oxytetracycline, tetracycline, minocycline, amoxicillin, chloramphenicol and cephaloglycin were reported at pH = 7.30 ± 0.01 in = 1.0 molL-1 NaClO4 used as supporting electrolyte at 25.0°C. Kinetic parameters viz. transfer coefficient (α), degree of irreversibility (λ) and rate constant (k) were determined. The study showed that ‘Transition state’ behaves between reactant (O) and product (R) response to applied potential. The stability constants varied from 2.14 to 10.31 showing that these drugs or their complexes could be used against Zn toxicity.
References
M. Breiter, M, Kleinerman, P. Delahay, J. Am. Chem. Soc. 80(1996) 5111.
L. Meites, Polarographic Technique, Interscience Pub.,
New York, 1965.
F. Khan, Oxid. Commun. 28 (2007) 937.
P. W. Atkins, Physical Chemistry, Oxford Univ. Press,
Oxford, 1986.
F. Khan, J. Chin. Chem. Soc. 54 (2007) 673.
H. A. Latinen, E. I. Onstott., J. Am. Chem. Soc. 72 (1950)
L. S. Goodman, A.Gilman, The Pharmacological Basis of
Therapeutics, London, MacMillan, 1975.
C. R. Dawson, H. B. Ostler, L. Hanna, I. Hoshiwara, E. J.
Jawetz, Infect. Dis. 124 (1971) 255.
F. Khan, F. Khan, J. Chin. Chem. Soc. 52 (2005) 569.
A. Kesharwani, F. Khan, Bull. Electrochem. 18 (2002) 413.
T. Devries, J. L. Kroon, J. Am. Chem. Soc. 75 (1953)
P. J. Gellings, Electrochem. Ber. Bunsenges Phys. Chem.
(1962) 477.
J. J. Lingane, Chem. Rev. 29 (1941) 32.
W. B. Schaap, D. L. McMaster, J. Am. Chem. Soc. 82
(1961) 4699.
F. Khan, L. Tantuvay, J. Pharm. Biomed. Anal. 27 (2002)
F. Khan,. L. Tantuvay, Trans. SAEST. 35 (2000) 79.
C. R. Stephens, L. H. Conover, R. Pasternack, F. A.
Hochstein, W. T. Moreland, P. P. Regna, F. J. Pilgrim, K. J.
Brunnings, R. B. Woodward, J. Am. Chem. Soc. 76 (1954)
A. E. Martell, M. Calvin, Chemistry of Metal Chelate
Compounds, London: Prentice Hall, 1953
M. D. Walker, D. R. Williams, J. Chem. Soc. (Dalton)
1186.
R. Tamamushi, N. Tanaka, Z. Phys. Chem. Neue Folge.
(1963). 117.
R. Tamamushi, K. Ishibashi, N. Tanaka, Z. Phys. Chem.
Neue Folge 35 (1962) 209.
P. Delahay, Double Layer and Electrode Kinetics,
Interscience Pub., New York, 1965.

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